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化学学报
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化学学报 ›› 1957, Vol. 23 ›› Issue (5): 367-376. 上一篇    下一篇

论文

血吸虫病化学治疗的研究Ⅲ.双(对氨基苯氧基)硫间烷类化合物

黃知恆, 嵇汝運   

  1. 中国科学院药物研究所
  • 投稿日期:1957-04-24 发布日期:2013-06-03

CHEMOTHERAPEUTIC STUDIES ON SCHISTOSOMIASIS Ⅲ. BIS (P-AMINOPHENOXY) THIAALKANES

HUANG CHIH-HENG, KYI ZU-YOONG   

  1. Institute of Materia Medica, Aeademia Sinica, Shanghai
  • Received:1957-04-24 Published:2013-06-03

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对二(β-羟乙基)氨基苯酚与相应的α,ω-二氯代硫间烷缩合,形成1,5-双[对二(β-羟乙基)氦基苯氧基]-3-硫间戊烷(Ha)及1,8-双[对二(β-羟乙基)氨基苯氧基]-3,6-二硫间辛烷(Ⅲa)。对苯亚甲氦基苯酚同样缩合并再水解后变为1,5-双(对氨基苯氧基)-3-硫间戊烷(Ⅱb)及1,8-双(对氨基苯氧基)-3,6-二硫间辛烷(Ⅲb)。3-对硝基苯氧基丙硫醇分别与二碘甲烷及溴化乙烯缩合,并将产物还原后形成1,9-双(对氨基苯氧基)-4,6-二硫间壬烷(Ⅲ-d)及1,10-双(对氨基苯氧基)-4,7-二硫间癸烷(Ⅲe),后者并又制成其N-甲烷磺酸钠衍生物(Ⅲf)。

Diaminodiphenoxyalkanes (I) have been reported to be active schistosomicides[3], but have a toxic effect on eyes[4].Attempts have been made in tho present work to modify their structures so as to retain the therapeutic activity, but to eliminate the side actions, and the preparation of some bis (p-aminophenoxy) thiaalkanes (Ⅱ) and bis (p-aminophenoxy) dithiaalkanes (Ⅲ) is now reportod.