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化学学报
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化学学报 ›› 1957, Vol. 23 ›› Issue (5): 385-390. 上一篇    下一篇

论文

从Mannich硷制备数种β-甲氧基-硝基苯丙酮

高怡生, 徐修容, 陳志豪, 陸順興, 翁尊堯, 潘百川, 陳潤蓮   

  1. 中国科学院药物研究所 上海
  • 投稿日期:1957-05-21 发布日期:2013-06-03

SYNTHESIS OF SEVERAL β-METHOXY-MTROPROPIOPHENONES FROM MANNICH BASES

Kao Yee-Sheng, Hsu Shiu-Yun, Chen Chi-Ao, Loh Shuen-Hsing, Owen Tsung-Yao, Pan Pei-Chuan, Chen Jen-Lien   

  1. Institute of Materia Medica, Academia Sinica, Shanghai
  • Received:1957-05-21 Published:2013-06-03

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(1)从Mannich碱β-二甲(或二乙)氨基-对(间或隣)-苯丙酮经过改良的真空降解法获得了对(或间或隣)-硝基苯乙烯酮。(2)对(或间或隣)-硝基苯乙烯酮与溴作用均生成其相应的双溴化合物。(3)直接从Mannich硷,β-二甲氨基-硝基-(对,间,隣)苯丙酮,与甲醇及微量盐酸在封管中加热,可以获得β-甲氧基-(对,间,隣)苯丙酮,此法此文献上记载的一般方法为简便。

Ginsberg et al.[2] reported the failure of obtaining the p-nitrophenylvinylketone (Ⅱa from the corresponding Mannich base to usual degradation means.In the present, communication, a modified method of degradation of Mannich bases to compounds of vinylketone type has been devised.