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化学学报
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化学学报 ›› 1956, Vol. 22 ›› Issue (3): 188-193. 上一篇    下一篇

有机化学

嘧啶的研究：2,5-二酮-1,2,3,4,5,6,7,8-八氫化-1,3-二雜氮萘合成的試探：環己烷-二酮(1,3)及醛對尿素的反應

紀育澧, 吳元鎏   

  1. 中央卫生研究院藥物学系
  • 投稿日期:1956-02-28 发布日期:2013-06-04

PYRIMIDINE RESEARCH： ATTEMPT TO SYNTHESIZE 2,5-DIKETO-1,2,3,4,5,6,7,8-OCTAHYDRO-QUINAZOLINE. THE REACTION OF CYCLOHEXANEDIONE(1,3)AND ALDEHYDE ON UREA

CHI YUOH-FONG, WU YUAN-LIU   

  1. Department of Therapeutics, Central Institute of Health
  • Received:1956-02-28 Published:2013-06-04

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環己烷二酮(1,3),隣氯代苯甲醛及尿素在乙醇-鹽酸中按照Biginelli式縮合反應生成4-(2'-氯代苯基)-2,5-二酮-1,2,3,4,5,6,7,8-八氫化-1,3-二雜氮萘。於上述反應中用正丁醛,对甲氧基苯甲醛或对二甲氨基苯甲醛代替隣氯代苯甲醛,作者未析出2,5-二酮-1,2,3,4,5,6,7,8-八氫化-1,3-二杂氮萘,而得到1,8-二酮-1,2,3,4,5,6,7,8,9,10-十氫化-10-杂氧蒽衍生物,所用尿素並未參加反應。

An attempt was made to synthesize 2,5-diketo-1,2,3,4,5,6,7,8-octahydro-quinazoline (I) through the application of a reaction similar to Biginelli condensation. 4-(2'-Chlorophenyl)-2,5-diketo-1,2,3,4,5,6,7,8-octahydro-quinazoline (I) (R=2'-Cl·C6H4-)，changing gradually at 2500 from the fine crystals into somewhat larger rectangular crystals and melting at 290-292°, was isolated through the condensation of cyclohexanedione-(1,3), o-chlorobenzaldehyde and urea in ethanol in presence of acid.