化学学报 ›› 1955, Vol. 21 ›› Issue (3): 328-331. 上一篇    下一篇

论文

中药白头翁中的皂硷素

朱任宏, 周韵簏   

  1. 中国科学院药物研究所 上海
  • 投稿日期:1955-06-22 发布日期:2013-06-04

THE SAPONIN OF CHINESE DRUG PAI-T’OU-WUNG, ANEMONE CHINENSIS BUNGE

CHU JEN-HUNG, CHOU YUN-LEE   

  1. Institute of Materia Medica,Academia Sinica,Shanghai
  • Received:1955-06-22 Published:2013-06-04

從白頭翁(Anemone Chinensis Bunge)中分得一皂鹼素,熔點不明顯,約在220-230°,水解後分得結晶皂鹼配醣基,其分子式為C27H44O4,熔點284°,[α]D17=+35.1°,並製得乙醯酯,熔點253°.糖的部分證實為葡萄糖.此外還分得一中性物質C30H52O10,熔點229-232°.

A saponin, m.p.220-2300, [α]D25=+35.1°40°, has been obtained in about 9% yield from the Chinese drug, Pai 2'ou-wung, which is usually used for the treatment of fever and dysentery.During hydrolysis with 5% sulphuric acid it gives a crystalline sapogenin with a m.p.2840, [α]D17=+35.1,and a molecular formula of C27H44O4, and a crystalline acetyl derivative, C27H43O4(CH3CO), m.p.253°, is prepared.Since these saponin and sapogenin differ in properties from those described in literature, anemosaponin and anemosapogenin are provisionally assigned as their names.The sugar part has been confirmed to be glucose through the formation of osazone.A second principle, C30H52O10 m.p.229-232°,has also been isolated from the ethereal extract of this drug.