新型不对称三齿多吡啶配体及其混配钌(Ⅱ)配合物的合成、表征及与DNA相互作用研究

化学学报 ›› 2004, Vol. 62 ›› Issue (7): 692-696. 上一篇下一篇

研究论文

新型不对称三齿多吡啶配体及其混配钌(Ⅱ)配合物的合成、表征及与DNA相互作用研究

蒋才武

广西中医学院药学院, 南宁, 530001

投稿日期:2003-08-12 修回日期:2003-10-19 发布日期:2014-02-18
通讯作者: 蒋才武,E-mail:cwjiang@gxtcmu.edu.cn;Fax:0771-3137377 E-mail:cwjiang@gxtcmu.edu.cn
基金资助:
广西中医学院高学历科研启动基金(No.G00217)和国家自然科学基金(No.30070188)资助项目.

Syntheses, Characterization and DNA-binding Studies of Novel Asymmetric Tridentate Polypyridine Ligands and Their Heteroleptic Ruthenium(Ⅱ) Complexes

JIANG Cai-Wu

School of Pharmacy, Guangxi Traditional Chinese Medical University, Nanning 530001

Received:2003-08-12 Revised:2003-10-19 Published:2014-02-18

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摘要/Abstract

合成了两个新型不对称三齿多吡啶配体,3-(1,10-菲咯啉基-2)-1,2,4-三唑(PHT), 3-(1,10-菲咯啉基-2)-5-甲基-1,2,4-三唑(PHMT),及其混配配合物[Ru(tpy)(PHT)]2+ (Ru1)和[Ru(tpy)(PHMT)]²⁺ (Ru2),通过元素分析、FAB-MS, ES-MS, ¹H NMR, IR, UV-vis,发射光谱和电化学对它们进行了表征.运用电子吸收光谱、竞争性结合实验和粘度测试等方法研究了配合物与DNA的作用机理,结果显示它们均是通过静电作用与DNA结合,且Ru2与DNA的作用比Ru1与DNA的作用更强.

关键词: 钌(Ⅱ)配合物, 三齿多吡啶配体, DNA结合模式

Two novel asymmetric tridentate polypyridine ligands with as-triazole, 3-(1,10-phenanthrolin-2-yl)-1,2,4-triazole (PHT) and 3-(1,10-phenanthrolin-2-yl)-5-methyl-1,2,4-triazole (PHMT) have been designed, synthesized, and characterized by microanalyses, FAB-MS, NMR, FT-IR, and UV-vis. Their heteroleptic complexes [Ru(tpy)(PHT)](ClO₄)₂·H₂O (Ru1) and [Ru(tpy)(PHMT)](ClO₄)₂ܨH₂O (Ru2) were synthesized and investigated with microanalyses, ES-MS, NMR and cyclic voltammetry. DNA binding mechanisms of the complexes were studied by electronic absorption spectra, competitive binding, and viscosity measurements. The results indicated that the modes of these two complexes interacting with DNA were electrostatic interaction, and the DNA-binding of Ru2 was stronger than that of Ru1.

Key words: ruthenium(Ⅱ)complex, tridentate polypyridine ligand, DNA binding

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蒋才武. 新型不对称三齿多吡啶配体及其混配钌(Ⅱ)配合物的合成、表征及与DNA相互作用研究[J]. 化学学报, 2004, 62(7): 692-696.

JIANG Cai-Wu. Syntheses, Characterization and DNA-binding Studies of Novel Asymmetric Tridentate Polypyridine Ligands and Their Heteroleptic Ruthenium(Ⅱ) Complexes[J]. Acta Chimica Sinica, 2004, 62(7): 692-696.

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参考文献

[1] Eriksson,M.;Leijon,M.;Hiort,C.;Norden,B.;Graslund,A.Biochemistry 1994,33,5031.
[2] Coggan,D.Z.M.;Haworth,I.S.;Bates,P.J.;Robinson,A.;Rodger,A.Inorg.Chem.1999,38,4486.
[3] Holmlin,R.E.;Stemp,E.D.A.;Barton,J.K.Inorg.Chem.1998,37,29.
[4] Friedman,A.E.;Chambron,J.C.;Sauvage,J.P.;Turro,N.J.;Barton,J.K.J.Am.Chem.Soc.1990,112,4960.
[5] Liu,J.-G.;Ye,B.-H.;Zhang,Q.-L.;Zou,X.-H.,Zhen,X.-T.;Ji,L.-N.J.Biol.Inorg.Chem.2000,5,119.
[6] Brodkorb,A.;Akirsch-De Mesmaeker,A.;Rutherford,T.J.;Keene,F.R.Inorg.Chem.2001,40,2151.
[7] Baker,A.D.;Morgan,R.J.;Strekas,T.C.J.Chem.Soc.,Chem.Commun.1992,1099.
[8] Constable,E.C.Prog.Inorg.Chem.1994,42,67.
[9] Constable,E.C.;Housecroff,C.E.;Neaburger,M.;Schneider,A.G.;Zehnder,M.J.Chem.Soc.,Dalton Trans.1997,2427.
[10] Pyle,A.M.;Rehmann,J.P.;Meshoyrer,R.;Kumar,C.V.;Turro,N.J.;Barton,J.K.J.Am.Chem.Soc.1989,111,3053.
[11] Wolfe,A.;Shimer,G.H.;Meehan,T.Biochemistry 1987,26,6392.
[12] Jain,S.C.;Tasai,C.C.;Sobell,H.M.J.Mol.Biol.1977,114,317.
[13] Satyanarayana,S.;Dabrowiak,J.C.;Chairs,J.B.Biochemistry 1993,31,9219.
[14] Satyanarayana,S.;Dabrowiak,J.C.;Chairs,J.B.Biochemistry 1993,32,2573.
[15] Chao,H.;Yang,G.;Xue,G.-Q.;Li,H.;Zang,H.;Williams,I.D.;Ji,L.-N.;Chen,X.-M.;Li,X.-Y.J.Chem.Soc.,Dalton Trans.2001,1326.
[16] Case,H.F.J.Heterocycl.Chem.1968,5,223.
[17] Sullivan,B.P.;Calvert,J.M.;Meyer,T.J.Inorg.Chem.1980,19,1404.
[18] Hage,R.;Haasnoot,J.G.;Reedijk,J.Inorg.Chim.Acta 1986,118,73.
[19] Corey,E.J.;Borror,A.L.;Foglia,T.J.Org.Chem.1965,30,288.
[20] Haga,M.-A.;Meser,A.M.;Koseki,S.;Fujimoto,K.;Yoshimura,A.;Nozaki,K.;Ohno,T.;Nakajima,K.;Stufkens,D.J.Inorg.Chem.1996,35,3335.
[21] Uda,M.;Hisazumi,Y.;Sato,K.;Kubota,S.Chem.Pharm.Bull.1976,24,3103.
[22] Hage,R.;Haasnoot,J.G.;Nieuwenhs,H.A.;Reedijk,R.;de Ridder,D.J.A.;Vos,J.G.J.Chem.Soc.,Dalton Trans.1990,2425.
[23] Juris,A.;Balzani,V.;Barigelletti,F.;Campagna,S.;Belser,P.;Vov Zelewsky,A.Coord.Chem.Rev.1988,34,85.
[24] Buchanan,B.E.;Wang,R.;Vos,G.J.;Hage,R.;Haasnoot,J.G.;Reedijk,R.Inorg.Chem.1990,29,3263.
[25] Jiang,C.-W.;Chao,H.;Li,H.;Ji,L.-N.J.Inorg.Biochem.2003,93,247.
[26] Morgan,O.;Wang,S.;Bae,S.-A.;Morgan,R.J.;Baker,A.D.;Strekas,T.C.;Engel,R.J.Chem.Soc.,Dalton Trans.1997,3773.
[27] Xue,X.;Lappin,A.G.Inorg.Chem.1995,34,992.
[28] Kuroda,R.;Saito,Y.Circular Dichroism Principles and Applications,Eds.: Nakanishi,K.;Berova,N.;Woody,R.W.,VCH Publishers,Inc.,New York,1994.
[29] Jackson,B.A.;Alekseye,V.Y.;Barton,J.K.Biochemistry 1999,38,4655.

新型不对称三齿多吡啶配体及其混配钌(Ⅱ)配合物的合成、表征及与DNA相互作用研究

Syntheses, Characterization and DNA-binding Studies of Novel Asymmetric Tridentate Polypyridine Ligands and Their Heteroleptic Ruthenium(Ⅱ) Complexes

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