研究论文

乌苏酸/DPPC 混合单层膜相互作用的研究

  • 王夫雨 ,
  • 孙润广 ,
  • 陈莹莹 ,
  • 王小梅 ,
  • 柴政
展开
  • 陕西师范大学 物理学与信息技术学院生物物理与生物医学工程研究室 西安 710062

收稿日期: 2011-06-23

  修回日期: 2011-10-17

  网络出版日期: 2011-11-22

基金资助

国家自然科学基金(No. 20772077)和教育部高等学校博士学科点专项科研基金(No. 200807180001)资助项目.

Monolayer Study on the Interaction between Ursolic Acid and DPPC

  • Wang Fuyu ,
  • Sun Runguang ,
  • Chen Yingying ,
  • Wang Xiaomei ,
  • Chai Zheng
Expand
  • Laboratory of Biophysics and Biomedical Engineering, College of Physics and Information Technology, Shaanxi Normal University, Xi'an 710062

Received date: 2011-06-23

  Revised date: 2011-10-17

  Online published: 2011-11-22

Supported by

Project supported by the National Natural Science Foundation of China (No. 20772077) and Doctoral Fund of Ministry of Education of China (No. 200807180001).

摘要

乌苏酸(UA)为五环三萜羧基酸类化合物, 是一种中药有效成分. 它进入细胞的过程与膜脂分子有密切关系. 选用生物膜系统中的膜脂分子二棕榈酰基磷脂酰胆碱(DPPC)为代表, 通过LB(Langmuir-Blodgett)膜技术获得乌苏酸与DPPC 混合单层膜的表面压力/平均分子面积(π-A)曲线. 分析了混合单层膜的平均和过量分子面积、弹性系数等热力学参量, 并用原子力显微镜进行了研究. 比较了乌苏酸/DPPC 与胆固醇/DPPC 混合单层膜的异同. 实验结果表明: 乌苏酸能促使DPPC 的凝聚; 乌苏酸/DPPC 两组分的物质的量比与混合单层膜的膜压对单层膜的压缩性、稳定性和热力学特性有影响, 对单层膜中不同组分间的混合性以及分子间的相互作用具有重要的影响.

本文引用格式

王夫雨 , 孙润广 , 陈莹莹 , 王小梅 , 柴政 . 乌苏酸/DPPC 混合单层膜相互作用的研究[J]. 化学学报, 2012 , 70(05) : 667 -673 . DOI: 10.6023/A1106233

Abstract

In this work, the interaction of urasolic acid (UA, a natural pentacyclic triterpene) and 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC, an important phospholipid in cell membrane) was investigated. The mean and excess surface area per molecule, elastic modulus, excess Gibbs energy, and interaction parameter of mixed monolayer were studied based on the surface pressure-area isotherms. The authors found that, as well as cholesterol, UA can induce the DPPC molecules on the monolayer condensation. The stability, compressibility and thermodynamic characteristics of binary system of UA and DPPC are connected with the surface pressure and the mole faction of UA. The AFM experiment supported the conclusion effectively.

参考文献

1 Chen, L. H.; Gan, L. H.; Liu, M. X.; Fan, R.; Xu, Z. J.; Hao, Z. X.; Chen, L. W. Appl. Surf. Sci. 2011, 257, 5070.  

2 Katarzyna, H. W.; Pawel, W. Chem. Phys. Lipids 2007, 150,22.  

3 Kim, D. K.; Baek, J. H.; Kang, C. M.; Yoo, M. A.; Sung, J. W.; Chung, H. Y.; Kim, N. D.; Choi, Y. H.; Lee, S. H.; Kim, K. W. Int. J. Cancer 2000, 87(5), 629.

4 Li, Y.; Xing, D.; Chen, Q.; Chen, W. R. Int. J. Cancer 2010,127, 462.

5 Zhang, Y. X.; Kong, C. Z.; Wang, L. H.; Li, J. Y.; Liu, X. K.; Xu, B.; Xu, C. L.; Sun, Y. H. J. Cell Biochem. 2010,109, 764.

6 Yang, L.; Liu, X.; Lu, Z.; Yuet-Wa C.J.; Zhou, L.; Fung, K. P.; Wu, P.; Wu, S. Cancer Lett. 2010, 298, 128.  

7 Yu, Y. X.; Gu, Z. L.; Yin, J. L.; Chou, W.H.; Kwok, C. Y.; Qin, Z. H.; Liang, Z. Q. Chin. Med. J. 2010, 14(123), 1915.

8 Wilson, J. M. Nature 1993, 365(6448), 691.

9 Limami, Y.; Pinon, A.; Leger, D. Y.; Mousseau, Y.; Cook- Moreau, J.; Beneytout, J. L.; Delage, C.; Liagre, B.; Alain, S. Biochimie 2011, 93, 749

10 Yu, L. B.; Wang, J.; Ma, B. Z.; Sun, W. Z. J. Sichuan Univ. (Med. Sci. Ed.) 2010, 41(6), 986 (in Chinese). (于丽波, 王晶, 马宝璋, 孙文洲, 四川大学学报(医学 版), 2010, 41(6), 986.)

11 Zhao, C. C.; Qian, Z. Z.; Wang, H. Q.; Song, C.; Meng, X. R.; Zhao, J.; Yan, Z.; Hao, X. S. Chin. J. New Drugs 2011,20(2), 147 (in Chinese). (赵翠翠, 钱正子, 王华庆, 宋拯, 孟祥睿, 赵静, 阎昭, 郝希山, 中国新药杂志, 2011, 20(2), 147.)  

12 Chen, Y.; Wu, Q. Q.; Zhang, Z. H.; Zhou, L.; Liu, X.; Du, M.; Jia, X. B. China J. Chin. Mater. Med. 2011, 36(8), 988 (in Chinese). (陈彦, 吴青青, 张振海, 周蕾, 刘璇, 杜萌, 贾晓斌, 中 国中药杂志, 2011, 36(8), 988.)

13 Su, Y. L.; Li, Q. Z.; Chen, L.; Yu, Z. W. Colloids Surf. A2007, 293, 123.  

14 Blodget, K. B. Phys. Rev. 1937, 51, 964.  

15 Hao, C. C.; Sun, R. G. Acta Chim. Sinica 2007, 65, 2325 (in Chinese). (郝长春, 孙润广, 化学学报, 2007, 65, 2325.)

16 Chang, Y. G.; Sun, R. G.; Hao, C. C.; Xue, H. J.; Han, T; Wang, X. M. Acta Chim. Sinica 2010, 68, 2181 (in Chinese). (常怡光, 孙润广, 郝长春, 薛慧君, 韩涛, 王小梅, 化学 学报, 2010, 68, 2181.)

17 Sun, R. G.; Hao, C. C.; Chang, Y. G.; Zhang, J.; Niu, C. L. Acta Chim. Sinica 2009, 67, 1808 (in Chinese). (孙润广, 郝长春, 常怡光, 张静, 牛春玲, 化学学报,2009, 67, 1808).

18 Hao, C. C.; Sun, R. G.; Zhang, J. Chem. J. Chin. Univ.2009, 30, 913 (in Chinese). (郝长春, 孙润广, 张静, 高等学校化学学报, 2009, 30,913.)

19 Yang, Y. P.; Tsay, R. Y. J. Lumin. 2007, 127, 186.  

20 Katarzyna, H. W.; Pawe?, W. Chem. Phys. Lipids 2007, 150,66.  

21 Hao, C. C.; Sun, R. G.; Zhang, J.; Chang, Y. G.; Niu, C. L. Colloids Surf., B 2009, 69, 201.  

22 Lee, Y. L.; Lin, J. Y.; Chang, C. H. T. J. Colloid Interface Sci. 2006, 296, 647.  

23 Hac-Wydro, K.; Dynarowicz-Latka, P.; Grzybowska, J.; Borowski, E. Thin Solid Films 2008, 516, 1197.  

24 Katarzyna, H. W.; Patrycja, D. Biophys. Chem. 2006, 123,154.  

25 Hao, C. C.; Sun, R. G.; Zhang, J.; Chang, Y. G.; Niu, C. L. Sci. China, Ser. B 2008, 38, 1018 (in Chinese). (郝长春, 孙润广, 张静, 常怡光, 牛春玲, 中国科学(B 辑), 2008, 38, 1018.)

26 Hac-Wydro, K.; Dynarowicz-?atka, P.; Grzybowska, J.; Borowski, E. Colloids Surf., B 2005, 46, 7.  

27 Barbara, G. M.; Maria, P. Thin Solid Films 2008, 516, 8865.  

28 Ronzon, F.; Desbat, B.; Chauvet, J. P.; Roux, B. Biochim. Biophys. Acta 2002, 1560, 1.  

29 Li, X. M.; Momsen, M. M.; Smaby, J. M.; Brockman, H. L.; Brown, R. E. Biochemistry 2001, 40, 5954.  

30 Kodama, M.; Shibata, O.; Nakamura, S.; Lee, S.; Sugihara, G. Colloids Surf., B 2004, 33, 211.  

31 Gong, K.; Feng, S. S.; Go, M. L.; Soew, P. H. Colloids Surf. A 2002, 207, 113.  

32 Bordi, F.; Cametti, C.; Venanzio, C. D.; Sennato, S.; Zuzzi, S. Colloids Surf., B 2008, 61, 304.  

33 Davies, J. T.; Rideal, E. K. Interfacial Phenomena, Academic Press, New York, 1963, p. 265.
文章导航

/