摘要 在无水磷酸钾催化下，以乙酰胺（CH3CONH2）和N-溴代丁二酰亚胺（NBS）为氮源和卤素源，丙酮作溶剂，建立了β-硝基苯乙烯双键上的区域专一性氨溴加成反应新体系。该法在室温下，无需惰性气体保护可高收率的获得邻位氨卤加成产物，最高收率可达79 % 。实验证明，当β-硝基苯乙烯中苯环4-位具有强供电子基团时（如CH3O），该反应的活性较低，同时得到唯一的α-氨基-β-二溴加成产物；当β-硝基苯乙烯中苯环4-位有强吸电子基团（如NO2）时，该反应的活性较高，同时也得到唯一的α-氨基-β-二溴加成产物。这一实验结果证明了β-硝基苯乙烯衍生物（缺电子烯键）在该条件下的氨溴加成反应是一个亲核加成反应。本文共考察了14种不同结构的β-硝基苯乙烯的氨溴加成反应情况，其产物结构经核磁共振氢谱、碳谱、及元素分析确证，并提出了可能的反应机理。

A regiospecific method for the aminobromination of β-nitrostyrene derivatives with acetamide and NBS as aminobrominating agent catalyzed by K3PO4 has been developed in acetone. The method can conveniently and efficiently convert β-nitrostyrenes into vicinal haloamines at room temperature in good yields up to 79 % and without the protection of an inert gaseous atmosphere. Strong electron-donating substituents(e.g.,OCH3) on the 4-position of benzene ring deactivated the reaction activity of β-nitrostyrenes and afforded a sole vicinal haloamine compound. Whereas strong electron-withdrawing substituents(e.g., NO2) activated reaction activity of them remarkably and afforded a sole vicinal haloamine compound, too. The result revealed that the addition reaction has an nucleophilic addition feature. The aminobromination of 14 examples of β-nitrostyrenes have been investigated in this work and the structure of all products were confirmed by their corresponding 1H NMR, 13C NMR spectra and their elemental analysis. A possible mechanism involving a nucleophilic conjugate addition was proposed.