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2012 , Vol. 70 >Issue 01: 92 - 98

DOI: https://doi.org/10.6023/A1111252

研究论文

PtBA-g-PPEGMEMA接枝共聚物的合成及其包埋阿霉素的研究

  • 郑兴良 ,
  • 丁爱顺 ,
  • 罗丹 ,
  • 高鸿盛
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  • 长沙理工大学化学与生物工程学院, 长沙 410076

收稿日期: 2011-11-25

  修回日期: 2011-12-19

  网络出版日期: 2012-02-25

基金资助

国家自然科学基金(No.20976017)和中国科学院上海有机化学研究所有机氟化学重点实验室开放基金2011资助项目.

收起

Synthesis of PtBA-g-PPEGMEMA Graft Copolymer and Its Loading of DOX

  • ZHENG Xing-Liang ,
  • DING Ai-Shun ,
  • LUO Dan ,
  • GAO Hong-Sheng
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  • Institute of Chemistry and Biological Engineering, Changsha University of Science and Technology, Changsha 410076

Received date: 2011-11-25

  Revised date: 2011-12-19

  Online published: 2012-02-25

Supported by

Project supported by the National Natural Science Foundation of China(No.20976017)and 2011 Foundation of Key Laboratory of Organofluorine Chemistry,Shanghai Institute of Organic Chemistry,CAS.

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摘要

通过可逆加成-裂解链转移聚合和原子转移自由基聚合,制备了以聚丙烯酸叔丁酯为主链、以聚(聚乙二醇单甲醚甲基丙烯酸酯)为侧链的两亲性接枝共聚物PtBA-g-PPEGMEMA,该方法克服了以往通过聚合物修饰来引入接枝点时所存在的接枝点密度不高和不可控的局限性.接着,以PtBA-g-PPEGMEMA为载体,对抗肿瘤药物阿霉素进行了负载,制备得到了尺寸为164.8nm的纳米载药胶束.其释放试验表明,该体系具有缓释特征.

关键词： 两亲性接枝共聚物; 可逆加成-裂解链转移聚合; 原子转移自由基聚合; 药物载体

本文引用格式

郑兴良 , 丁爱顺 , 罗丹 , 高鸿盛 . PtBA-g-PPEGMEMA接枝共聚物的合成及其包埋阿霉素的研究[J]. 化学学报, 2012 , 70(01) : 92 -98 . DOI: 10.6023/A1111252

Abstract

PtBA-g-PPEGMEMA amphiphilic graft copolymer,consisting of poly(tert-butylacrylate)back- bone and poly(poly(ethylene glycol)methyl ether methacrylate)side chains,was synthesized by the combi- nation of reversible addition-fragmentation chain transfer(RAFT)polymerization and atom transfer radical polymerization(ATRP).The limitation of low and uncontrolled grafting density while introducing the grafting points onto the polymer backbone by polymer post-modification can be overcome by this strategy.The anti-cancer drug,doxorubicin (DOX),was loaded using PtBA-g-PPEGMEMA as the carrier to get a DOX-loaded micelle-based nano-carrier with a Dh around 164.8nm.Drug release experiment of the nano-carrier indicated the delayed drug release characteristics.

Key words： amphiphilic graft copolymer; RAFT; ATRP; drug carrier

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