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2012 , Vol. 70 >Issue 02: 195 - 199

DOI: https://doi.org/10.6023/A1104254

研究论文

金属螺旋三角形穴状化合物的组装及其对氨基葡萄糖的识别研究

  • 吴红梅 ,
  • 郭宇
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  • 辽宁工业大学化学与环境工程学院 锦州 121001

收稿日期: 2011-04-25

  修回日期: 2011-09-20

  网络出版日期: 2012-02-25

基金资助

国家自然科学基金(No.20801008);辽宁省教育厅科学研究一般项目(No.L2011105)和辽宁工业大学教师科研启动基金(No.X201116)资助项目.

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Assembly of Metallohelical Triangle Cryptate for Recognition of Glucosamine

  • WU Hong-Mei ,
  • GUO Yu
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  • School of Chemical and Environmental Engineering, Liaoning University of Technology, Jinzhou 121001

Received date: 2011-04-25

  Revised date: 2011-09-20

  Online published: 2012-02-25

Supported by

Project supported by the National Natural Science Foundation of China (No.20801008);Science & Research Project of Liaoning Province Eduction Deparatment (No.L2011105);Teacher Start-up Fund of Science & Research Foundation of Liaoning University of Technology (No.X201116).

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摘要

利用含有丹磺酰胺荧光团和氢键作用位点的双三齿(N2O)有机配体H2L1[(N-(3,5-双(2-(2-吡啶亚甲基)甲酰肼基))苯基)-5-(二甲基氨基)萘-1-磺酰胺]与Zn2+构筑金属螺旋三角形穴状化合物MC-1. 通过荧光光谱、紫外光谱和ESI-MS测试及1H NMR 测定, 研究其对氨基葡萄糖和葡萄糖的识别与传感. 结果表明, MC-1 对氨基葡萄糖具有良好的荧光和紫外双重响应, 而对葡萄糖却没有任何响应, 且MC-1 能够1:1 包合氨基葡萄糖, 平衡常数lgKass=7.23±0.03.

关键词： 穴状化合物; 氨基葡萄糖; 丹磺酰胺; 识别

本文引用格式

吴红梅 , 郭宇 . 金属螺旋三角形穴状化合物的组装及其对氨基葡萄糖的识别研究[J]. 化学学报, 2012 , 70(02) : 195 -199 . DOI: 10.6023/A1104254

Abstract

Metallohelical triangle cryptate MC-1 was assembled by Zn2+ and two tridentate (N2O) ligand H2L1 [N-(3,5-bis((E)-2-(pyridin-2-ylmethylene)hydrazinecarbonyl)phenyl)-5-(dimethylamino)napthalene-1-sulfonamide] with dansyl sulfonamide group and hydrogen bond site. UV-vis and fluorescence spectra, ESI-MS and 1H NMR of MC-1 were measured for recognition of glucosamine and glucose. It was found that MC-1 exhibited good response of UV-vis and fluorescene toward glucosamine, but no response for glucose. Moreover, 1:1 stoichiometric host-guest complexation of MC-1 for glucosamine was confirmed by the titration profile and electrospray ionization mass spectrometry (ESI-MS) spectrum, with an association constant (lgKass) being calculated as 7.23±0.03.

Key words： cryptate; glucosamine; dansyl sulfonamide; recognition

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