SIOC English
化学学报
高级检索

化学学报 >

2012 , Vol. 70 >Issue 03: 357 - 362

DOI: https://doi.org/10.6023/A1107101

研究论文

新型含2,5-二-(3,5-二甲基吡唑-4-巯基)-1,3,4-噻二唑-M (M＝Co2+, Cd2+, Mn2+)配合物的合成、晶体结构及其抑菌活性研究

  • 张奇龙 ,
  • 袁泽利 ,
  • 张云黔 ,
  • 朱必学
展开
  • a 贵阳医学院化学教研室 贵阳 550004;
    b 遵义医学院药学系 遵义 563003;
    c 贵州省大环化学及超分子化学重点实验室 贵阳 550025

收稿日期: 2011-07-10

  修回日期: 2011-09-05

  网络出版日期: 2011-10-25

基金资助

国家自然科学基金(No. 21061003)、贵州省自然科学基金(No. [2011]2287)资助项目.

收起

Synthesis, Crystal Structure and Bacteriostatic Activity of M (M＝Co2+, Cd2+, Mn2+) Complex with 2,5-Bis(3,5- dimethylpyrazol-4-thio)-3,4-thiadiazole

  • ZHANG Qi-Long ,
  • YUAN Ze-Li ,
  • ZHANG Yun-Qian ,
  • ZHU Bi-Xue
Expand
  • a Department of Chemistry, Guiyang Medical College, Guiyang 550004;
    b Department of Pharmacy, Zhunyi Medical College, Zhunyi 563003;
    c Key Laboratory of Macrocycle and Supramolecular Chemistry, Guiyang 550025

Received date: 2011-07-10

  Revised date: 2011-09-05

  Online published: 2011-10-25

Supported by

This work was supported by the National Natural Science Foundation of China (No. 21061003) and the Natural Science Foundation of Guizhou Province (No. [2011]2287).

Fold

摘要

将配体L [2,5-二-(3,5-二甲基吡唑-4-巯基)-1,3,4-噻二唑]与Co(NO3)2·6H2O, Cd(NO3)2·4H2O 和MnCl2·4H2O 进行配位反应, 得到三个配合物[Co(L)2(H2O)4](NO3)2 · 4(CH3CH2OH) (1), [Cd(L)2(H2O)4](NO3)2 · 4(CH3CH2OH) (2),[Mn(L)2(Cl)2(CH3OH)2]·2(CH3OH) (3), 并用元素分析, FT-IR 和X 射线单晶衍射进行了表征. 分析结果表明, 配体L 呈“U”形, 配合物1～3 呈“S”形. 配合物中Co(Ⅱ), Cd(Ⅱ), Mn(Ⅱ)的配位环境均为扭曲八面体, 每个金属离子同时和两个配体进行配位. 配体和配合物体外抑菌活性研究结果表明, 配体及其配合物都有一定的抑菌活性.

关键词： 配合物; 晶体结构; 抑菌活性

本文引用格式

张奇龙 , 袁泽利 , 张云黔 , 朱必学 . 新型含2,5-二-(3,5-二甲基吡唑-4-巯基)-1,3,4-噻二唑-M (M＝Co2+, Cd2+, Mn2+)配合物的合成、晶体结构及其抑菌活性研究[J]. 化学学报, 2012 , 70(03) : 357 -362 . DOI: 10.6023/A1107101

Abstract

Three complexes [Co(L)2(H2O)4](NO3)2·4(CH3CH2OH)(1), [Cd(L)2(H2O)4](NO3)2·4(CH3CH2- OH) (2) and [Mn(L)2(Cl)2(CH3OH)2]·2(CH3OH) (3) were synthesized from the reaction of 2,5-bis(3,5- dimethylpyrazol-4-thio)-3,4-thiadiazole with Co(NO3)2·6H2O, Cd(NO3)2·4H2O and MnCl2·4H2O, and characterized by elemental analysis, FT-IR and single crystal X-ray diffraction. The results of structural analysis indicate that the ligand (L) was adopted “U” configuration, and each complex shows a “S” conformation. In three complexes, the coordination environment of each metal center show a distorted octahedral geometry, and each metal ion was coordinated with two ligands. The bacteriostatic activity results indicated that both of the ligand and complexes possess some bacteriostatic effect.

Key words： complex; crystal structure; bacteriostatic activity

参考文献

1 Singh, N. K.; Misseema Agrawal, R. C. Synth. React. Inorg. Met. Org. Chem. 1985, 15, 75.  

2 Yang, X.-L.; Chen, F. H. Chem. J. Chin. Univ. 1995, 16, 234 (in Chinese). (杨新玲, 陈馥衡, 高等学校化学学报, 1995, 16, 234.)

3 Tzeng, B. C.; Wu, Y. L. New J. Chem. 2007, 31, 199.

4 Xu, F. L. Anhui Chem. Ind. 2010, 36, 17 (in Chinese). (许方亮, 安徽化工, 2010, 36, 17.)

5 Lou, X. H.; Zhu, Y.; Gao, H.; Zhu, A. X. Chin. J. Inorg. Chem. 2005, 21, 716 (in Chinese). (娄新华, 朱玉, 高辉, 朱爱新, 无机化学学报, 2005, 21, 716.)

6 Wang, W. X.; Zhao, H. Chin. J. Inorg. Chem. 2010, 26, 1109 (in Chinese). (王文祥, 赵红, 无机化学学报, 2010, 26, 1109.)

7 Shan, N.; Vickers, S. J. Angew. Chem., Int. Ed. Engl. 2004, 43, 3938.  

8 Gaynor, D.; Starikova, Z. A. Chem. Commun. 2002, 506.  

9 Jennifer, A. T.; Adam, G.; Michael, P. Bioorg. Med. Chem. Lett. 2004, 14, 4945.  

10 Sharp, S.; Boxall, K.; Matthews, T. Eur. J. Cancer Supplements 2004, 2, 105.

11 Zou, X. M.; Cheng, Y. H.; Ren, X. L.; Hu, F. Z.; Yang, H. Z. Chin. J. Org. Chem 2005, 25, 554 (in Chinese). (邹小毛, 程永浩, 任雪玲, 胡方中, 杨华铮, 有机化学, 2005, 25, 554.)

12 Liu, Z. L.; Lei, X.; Liu, W. C. Chin. J. Synth. Chem. 1997, 5, 394 (in Chinese). (刘长令, 雷新, 刘武成, 合成化学, 1997, 5, 394.)

13 Xia, Q. C.; He, Q. Z.; Xu, D. F.; Sun, D. Z.; Peng, Z. F. Acta Chim. Sinica 2010, 68, 2414 (in Chinese). (夏庆春, 何其庄, 许东芳, 孙大志, 彭子飞, 化学学报,  

2010, 68, 2414.)

14 Zhang, X. F.; Chen, H.; Ma, C. B.; Liu, Q. T. Dalton Trans. 2006, 4047.

15 Sheldrick, G. M. SHELXL-97, Program for Crystal Structure Determination, University of Gottingen, Germany, 1997.  
Options
文章导航

/

〈 〉