SIOC English
化学学报
高级检索

化学学报 >

2012 , Vol. 0 >Issue 04: 519 - 524

DOI: https://doi.org/10.6023/A1109102

研究简报

铋(III)苯乙酸-1,10-邻菲罗啉三元配合物[Bi2(PPA)6·(Phen)2]的合成、 晶体结构及抑菌活性

  • 杨树平 ,
  • 韩立军 ,
  • 潘燕 ,
  • 吴争鸣 ,
  • 何欣然 ,
  • 陈丽娟
展开
  • a 淮海工学院化学工程学院 连云港 222005;
    b 淮海工学院数理学院 连云港 222005222005;
    c 北京大学医学部基础医学院药理系及国家天然仿生药物重点实验室 北京 100191

收稿日期: 2011-09-10

  修回日期: 2011-11-18

  网络出版日期: 2011-12-19

基金资助

国家自然科学基金(No. 30901815)和淮海工学院自然科学基金(No. Z2009019)资助项目.

收起

Synthesis, Crystal Structure and Antibacterial Activity of A Bismuth(III) Complex [Bi2(PPA)6?(Phen)2] with Phenylacetic Acid and 1,10-Phenanthroline

  • Yang Shuping ,
  • Han Lijun ,
  • Pan Yan ,
  • Wu Zhenming ,
  • He Xinran ,
  • Chen Lijuan
Expand
  • a School of Chemical Engineering, Huaihai Institute of Technology, Lianyungang 222005;
    b School of Mathematics and Science, Huaihai Institute of Technology, Lianyungang 222005;
    c Department of Pharmacology, School of Basic Medical Sciences and State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191

Received date: 2011-09-10

  Revised date: 2011-11-18

  Online published: 2011-12-19

Supported by

Project supported by the National Natural Science Foundation of China (No. 30901815) and Natural Science Foundation of Huaihai Institute of Technology, China (No. Z2009019).

Fold

摘要

合成了铋(III)苯乙酸-1,10-邻菲罗啉[Bi2(PPA)6·(Phen)2] (HPPA＝苯乙酸(C8H7O2), Phen ＝ l,10-邻菲罗啉 (C12H8N2))三元配合物, 并通过元素分析和红外(IR)光谱对其进行了表征, 用单晶X-射线衍射测定了配合物的晶体结构. 配合物属于三斜晶系, P-1 空间群, a＝0.9100(6) nm, b＝1.2617(8) nm, c＝1.3324(9) nm, α＝89.757(8)°, β＝ 87.277(8)°, γ＝81.155(8)°, V＝1.5099(17) nm3, Dc＝1.748 g·cm-3, μ＝5.890 mm-1, Z＝1, F(000)＝780, 残差因子R1＝ 0.0484, wR2＝0.1090 [I>2σ(I)], S＝1.002. 标题化合物为双核铋(III)配合物, 金属中心Bi(III)原子与三个苯乙酸根(PPA) 中的6 个氧原子、一个1,10-邻菲罗啉分子中的两个氮原子和一个桥连氧原子进行配位, 形成九配位的扭曲三帽三方柱配位十四面体, 围绕铋原子的价键总数VBi(1)＝2.897, 两个Bi(III)原子通过两个桥连氧原子连结成中心对称的分子, Bi…Bi 间距离为0.4469(2) nm. 初步抑菌试验结果显示, 配合物对大肠杆菌(E. Coli)、金黄色葡萄球菌(S. Aureus)、枯草芽孢杆菌(B. Subtilis)表现出相似且良好的抑菌效果.

关键词： 铋(III)配合物; 晶体结构; 抗菌活性; 苯乙酸; 邻菲罗啉

本文引用格式

杨树平 , 韩立军 , 潘燕 , 吴争鸣 , 何欣然 , 陈丽娟 . 铋(III)苯乙酸-1,10-邻菲罗啉三元配合物[Bi2(PPA)6·(Phen)2]的合成、 晶体结构及抑菌活性[J]. 化学学报, 2012 , 0(04) : 519 -524 . DOI: 10.6023/A1109102

Abstract

A bismuth(III) complex [Bi2(PPA)6·(Phen)2] (HPPA ＝ phenylacetic acid; Phen ＝ 1,10-phenanthroline) was synthesized and characterized by elemental analysis and infrared (IR) spectroscopy, its crystal structure was determined by single crystal X-ray diffraction. The crystal of bismuth(III) complex belongs to triclinic system with space group P-1, a＝0.9100(6) nm, b＝1.2617(8) nm, c＝ 1.3324(9) nm, α＝89.757(8)°, β＝87.277(8)°, γ＝81.155(8)°, V＝1.5099(17) nm3, Dc＝1.748 g·cm-3, μ＝5.890 mm-1, Z＝1, F(000)＝780, residual factors R1＝0.0484, wR2＝0.1090 [I>2σ(I)], S＝1.002. The comcomplex is a binuclear bismuth(III) compound, and every bismuth(III) atom is nine-coordinated by six O atoms from three ligands (PPA) and two N atoms from one ligand (Phen) and one bridged O atom, and the coordination polyhedron around the bismuth(III) atom can be best described as a distorted tricapped trigonal-prismatic tetrakaidecahedron geometry, the valence sum of around Bi atom VBi(1)＝2.897. The distance of Bi…Bi is 0.4469(2) nm. The complex has a good effect against E. Coli, S. Aureus and B. Subtilis.

Key words： bismuth(III) complex; crystal structure; antibacterial activity; phenylacetic acid; 1,10-phenanthroline

参考文献

1 Beales, I. LP. BMC Gastroenterology 2001, 1, 7.  

2 Yang, N.; Sun, H.-Z. Coord. Chem. Rev. 2007, 251(17～20), 2354.

3 Suarez, F. L.; Furne, J.; Stiehm, J.; Garten, C.; Levitt, M. D. Dig. Dis. Sci. 2000, 45(7), 1444.  

4 Dante, F.-Q.; Eduardo, S.-L.; R. Bradley, S.; Raul, L.-B.; Silvana, S.-A.; Miguel, C.-S.; Eduardo, E.-M. N. Engl. J. Med. 1993, 328(23), 1653.  

5 Nie, Y.; Li, Y.; Wu, H.; Sha, W.; Du, H.; Dai, S.; Wang, H.; Li, Q. Helicobacter 1999, 4(2), 128.  

6 Kotani, T.; Nagai, D.; Asahi, K.; Suzuki, H.; Yamao, F.; Kataoka, N.; Yagura, T. Antimicrob. Agents Chemother. 2005, 49(7), 2729.

7 Nomiya, K.; Sekino, K.; Ishikawa, M.; Honda, A.; Yokoyama, M.; Kasuga, N. C.; Yokoyama, H.; Nakano, S.; Onodera, K. J. Inorg. Biochem. 2004, 98(2), 601.

8 Murafuji, T.; Fujiwara, Y.; Yoshimatsu, D.; Miyakawa, I.; Migita, K.; Mikata, Y. Eur. J. Med. Chem. 2011, 46(2), 519.

9 Philip, C.; Andrews, R. F.; Peter, C.; Junk, L. K.; Ish Kumar, J. G. M. J. Inorg. Biochem. 2011, 105(3), 454.  

10 Li, H.-Y.; Lai, C. S.; Wu, J. Z.; Paul, C.; Dick de Vos, H.; Tiekink, E. R. T. J. Inorg. Biochem. 2007, 101(5), 809.  

11 Smith, K. A.; Deacon, G. B.; Jackson, W. R.; Tiekink, E. R. T.; Rainone, S.; Webster, L. K. Met.-Based Drugs 1998, 5(5), 295.  

12 Wang, X.-Y.; Zhang, X.-M.; Lin, J.; Chen, J.-W.; Xu, Q.; Guo, Z.-J. J. Chem. Soc., Dalton Trans. 2003, 2379.  

13 Zhang, Z.-P.; Zhong, G.-Q.; Jiang, Q.-Y. Prog. Chem. 2008, 20(9), 1315 (in Chinese). (张志朋, 钟国清, 蒋琪英, 化学进展, 2008, 20(9), 1315.)  

14 Stavila, V.; Davidovich, R. L.; Gulea, A.; Whitmire, K. H. Coord. Chem. Rev. 2006, 250, 2782.  

15 Viossat, V.; Lemoine, P.; Dayan, E.; Dung, N.-H.; Viossat, B. J. Mol. Struct. 2005, 741(1～3), 45.  

16 Gup, R.; K?rkan, B. Spectrochim. Acta, Part A 2006, 64(3), 809.

17 Xu, H.-H.; Gu, J.-M. Chin. J. Inorg. Chem. 1998, 14(2), 237 (in Chinese). (徐号华, 顾建明, 无机化学学报, 1998, 14(2), 237.)  

18 Jiang, Q.-Y.; Shen, J.; Zhong, G.-Q. Prog. Chem. 2006, 18(12), 1634 (in Chinese). (蒋琪英, 沈娟, 钟国清, 化学进展, 2006, 18(12), 1634.)

19 Sun, X.-D.; Sun, Y. Chem. Res. Appl. 2009, 21(9), 1275 (in Chinese). (孔晓朵, 孙怡, 化学研究与应用, 2009, 21(9), 1275.)

20 Li, W.; Li, C.-H.; Yang, Y.-Q.; Xie, H.-P. Chin. J. Inorg. Chem. 2009, 25(6), 1106 (in Chinese). (李薇, 李昶红, 杨颖群, 谢和平, 无机化学学报, 2009, 25(6), 1106.)

21 Le, X.-Y.; Yang, G.; Lu, Q.-M. Chin. J. Inorg. Chem. 2002, 18(4), 427 (in Chinese). (乐学义, 杨光, 卢其明, 无机化学学报, 2002, 18(4), 427.)

22 Sheldrick, G. M. Acta Cryst. A 2008, 64(1), 112.

23 Brandenburg, K. Diamond, Crystal Impact GbR, Bonn, Germany, 1999.  

24 Liu, G.-Z. Micro-biology and the Detect of Micro-biology, People’s Medical Publish House, Beijing, 1987, p. 100 (in Chinese). (刘恭植, 微生物学和微生物学检验, 人民卫生出版社, 北京, 1987, p. 100.)

25 Nakamoto, K. Infrared and Raman Spectra of Inorganic and Coordination Compounds, Trans. Huang, D. R.; Wang, R. Q. Chemical Industrial Press, Beijing, 1986, p. 235 (in Chinese). (中本一雄, 无机和配位化合物的红外和拉曼光谱, 黄德 如, 汪仁庆译, 化学工业出版社, 北京, 1986, p. 235.)  

26 Gao, S.; Zhang, Z.-Y.; Huo, L.-H.; Zhao, H.; Zhao, J.-G. Chin. J. Inorg. Chem. 2005, 21(5), 771 (in Chinese). (高山, 张竹艳, 霍丽华, 赵辉, 赵经贵, 无机化学学报, 2005, 21(5), 771.)

27 Yu, Y.-Y.; Liu, J.-F.; Li, H.-Q.; Zhao, G.-L. Acta Phys.-Chim. Sin. 2010, 26(6), 1535 (in Chinese). (余玉叶, 刘建风, 李花琼, 赵国良, 物理化学学报, 2010, 26(6), 1535.)

28 Ying, H.-D.; Wang, C.-H.; Xu, F.-Q. Chin. J. Inorg. Chem. 2004, 20(3), 345 (in Chinese). (尹汉东, 王传华, 许福泉, 无机化学学报, 2004, 20(3), 345.)  

29 Zhong, G.-Q.; Chen, M.-J.; Jiang, Q.-Y.; Zhang, Z.-P. J. Inorg. Synth. Cryst. 2010, 39(1), 281 (in Chinese). (钟国清, 陈明剑, 蒋琪英, 张志朋, 人工晶体学报, 2010, 39(1), 281.)  

30 Guo, Y.-C.; Zhuo, L.-H. Chem. Res. 2003, 14(2), 39 (in Chinese). (郭应臣, 卓立宏, 化学研究, 2003, 14(2), 39.)

31 Brese, N. E.; O'Keeffe, M. Acta Cryst. B 1991, 47(2), 192.  

32 Brown, I. D. The Chemical Bond in Inorganic Chemistry, Oxford University Press, Oxford, 2002.  

33 Brown, I. D.; Altermatt, D. Acta Cryst. B 1985, 41(4), 244.  

34 Hu, S.-Z.; Chen, M.-D.; Robertson, B. E. Acta Phys.-Chim. Sin. 2005, 21(6), 646 (in Chinese). (胡盛志, 陈明旦, Robertson, B. E. 物理化学学报, 2005, 21(6), 646.)

35 Hodgson, D. J.; Asplund, R. O. Acta Cryst. C 1991, 47(9), 1986.  

36 Xia, Q.-C.; Shen, Z.-H.; He, Q.-Z.; Xu, D.-F.; Peng, Z.-F.; Shao, C.-Y. Acta Chim. Sinica 2009, 67(16), 1843 (in Chinese). (夏庆春, 沈智慧, 何其庄, 许东芳, 彭子飞, 邵超英, 化 学学报, 2009, 67(16), 1843.)
Options
文章导航

/

〈 〉