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2013 , Vol. 71 >Issue 05: 717 - 721

DOI: https://doi.org/10.6023/A13020198

研究论文

钯催化下肟醚导向的sp2 C—H键邻位酰氧化反应

  • 蔡海婷 ,
  • 李丹丹 ,
  • 刘姿 ,
  • 王官武
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  • 中国科学技术大学化学系 合肥微尺度物质科学国家实验室 合肥 230026

收稿日期: 2013-02-19

  网络出版日期: 2013-03-21

基金资助

项目受国家自然科学基金(No. 91021004)和安徽省高校省级自然科学研究重大项目(No. KJ2010ZD05)资助.

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Palladium-Catalyzed Decarboxylative ortho-Acylation of O-Methyl Ketoximes via Direct sp2 C—H Bond Activation

  • Cai Haiting ,
  • Li Dandan ,
  • Liu Zi ,
  • Wang Guanwu
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  • Department of Chemistry and Hefei National Laboratory for Physical Sciences at Microscale, University of Science and Technology of China, Hefei, Anhui 230026

Received date: 2013-02-19

  Online published: 2013-03-21

Supported by

Project supported by the National Natural Science Foundation of China (No. 91021004) and the Intercollegiate Key Project of Natural Sciences of Anhui Province, China (No. KJ2010ZD05).

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摘要

使用醋酸钯作为催化剂, 过硫酸钠和氧化银为氧化剂, 使肟醚导向的底物与苯甲酰甲酸发生sp2 C—H键的邻位酰氧化反应, 从而得到芳香酮类化合物. 该方法对带吸电子基和给电子基的反应物都有很好的适应性, 最高产率可达98%.

关键词： 钯催化; C—H键活化; 肟醚导向; 脱羧; 酰基化

本文引用格式

蔡海婷 , 李丹丹 , 刘姿 , 王官武 . 钯催化下肟醚导向的sp2 C—H键邻位酰氧化反应[J]. 化学学报, 2013 , 71(05) : 717 -721 . DOI: 10.6023/A13020198

Abstract

The palladium-catalyzed decarboxylative ortho-acylation of O-methyl ketoximes with α-oxocarboxylic acids in the presence of Na2S2O8 and Ag2O is demonstrated. This protocol can be applied to various O-methyl ketoximes and α-oxocarboxylic acids with both electron-donating and electron-withdrawing groups with products yields up to 98%.

Key words： palladium catalysis; C—H bond activation; O-methyl ketoximes-directed; decarboxylation; acylation

参考文献

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