聚乳酸自支持膜的叠加及其作为药物控释阻隔层的研究
收稿日期: 2014-08-08
修回日期: 2014-09-06
网络出版日期: 2014-09-06
基金资助
项目受国家自然科学基金(No. 21174024)、辽宁省高等学校优秀人才支持计划(No. LR2012008)和中央高校基本科研业务费(Nos. N120505005， N120405007， N130305002， N130205001)资助.
Fabrication of Poly(lactic acid) Multilayer by Superimposing Free-standing Films for Controlled Drug Delivery
Received date: 2014-08-08
Revised date: 2014-09-06
Online published: 2014-09-06
Supported by
Project supported by the National Natural Science Foundation of China (No. 21174024), Program for Liaoning Excellent Talents in University (No. LR2012008), and the Fundamental Research Funds for the Central Universities (Nos. N120505005, N120405007, N130305002, N130205001).
发展了一种将自支持膜层层叠加制备多层膜的新方法，并研究了该薄膜对药物释放的调控效果. 首先利用聚乙烯醇作为牺牲层制备出聚乳酸自支持膜，然后将聚乳酸自支持膜转移或层层叠加到载药薄膜表面，最后对覆盖有聚乳酸薄膜的载药膜进行药物释放研究. 实验结果表明，聚乳酸薄膜对药物的释放起到了明显的调节作用，并且转移的薄膜的控释效果优于原位制备的薄膜，多层叠加的薄膜控释效果强于同等厚度的单层薄膜. 这可能是由于转移和叠加的薄膜层与层之间的空隙对药物的释放起到了缓冲作用所致. 这种基于自支持膜叠加制备多层膜的方法为药物涂层的研究提供了新思路，在生物材料、医用植入器件等领域都有一定的发展前景.
李妍 , 杨盛 , 何桂丽 , 焦永华 , 付昱 , 孙挺 . 聚乳酸自支持膜的叠加及其作为药物控释阻隔层的研究[J]. 化学学报, 2014 , 72(10) : 1110 -1114 . DOI: 10.6023/A14080575
A new method has been developed to fabricate multilayer films by superimposing free-standing films and the resulting film was utilized as the barrier coating to control the drug release. First, the poly(lactic acid) (PLA) free-standing film was prepared by using polyvinyl alcohol (PVA) as a sacrificial layer. Then the PLA film was transferred or layer-by- layer overlaid on the drug-loaded film. Finally, the drug release process of the as-covered drug-loaded film was investigated. The prepared PLA free-standing film was smooth and robust, and the thickness increased linearly with the solution concentration. It is worth mentioning that on the bottom surface of the PLA film there was the PVA residue from the sacrificial layer, which can't be completely removed. That may facilitate the fabrication of the multilayer by superimposing because the PVA could provide interaction between the layers through hydrogen bonding. The free-standing films with about 50, 100 and 200 nm thickness were transferred and overlaid. The SEM observation shown that the transferred film could fully cover the target surface and the morphology was basically smooth. The thickness of the multilayer film was in agreement with the expected value. All of these indicated that the multilayer fabrication was successful. The multilayer PLA films can efficiently control the drug release. Moreover, the transferred film was more efficient than the in-situ spin film and the multilayer film was more efficient than the monolayer film. This may be attributed to the gap between the transferred free-standing films, which holds the released drug, retarding the release rate. The concept to fabricate the multilayer by superimposing free-standing film provides a new approach to control drug release and has great potential in the biological materials and medical implant devices.
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