收稿日期: 2017-11-22
网络出版日期: 2018-01-09
基金资助
项目受国家重大科学研究计划（973项目，No.2014CB965003）资助.
A Review: Biodegradation Strategy of Graphene-Based Materials
Received date: 2017-11-22
Online published: 2018-01-09
Supported by
Project supported by the National Key Basic Research Program of China (973 Program, No. 2014CB965003).
自2004年被发现以来，前沿新材料石墨烯及其衍生物由于其独特的电学、光学和力学性能被广泛关注，在许多领域都展露了光彩，包括新型电池、传感器、新能源和生物医学等领域，尤其在生物医药领域发展迅速.石墨烯及其衍生物良好的生物相容性使其在生物领域中具有重要的应用前景.为了实现石墨烯材料的体内应用，材料的可降解性是值得深入研究的焦点，研究其生物降解行为有助于提高其对环境、生命系统的安全性.到目前为止，石墨烯的生物降解研究主要集中在材料的生物酶促降解，利用一系列方法如异质原子掺杂、表面功能化修饰等对石墨烯材料进行改性，可以调控石墨烯材料的降解.综述了近年来石墨烯材料及其衍生物在生物应用上的降解的研究进展，重点介绍石墨烯的酶促降解和其在生物医学领域的应用前景，为进一步促进石墨烯材料的体内研究提供重要的研究基础和指导意义.
赵克丽 , 郝莹 , 朱墨 , 程国胜 . 石墨烯材料生物降解的策略研究[J]. 化学学报, 2018 , 76(3) : 168 -176 . DOI: 10.6023/A17110499
Since its discovery in 2004, the new frontier materials graphene and its derivatives have attracted a great deal of attention on the fields of new batteries, sensors, new energy and biomedicine, due to their unique electrical, optical and mechanical properties. Specifically, it has been developed rapidly in the biomedical field. The good biocompatibility has endowed graphene and its derivatives great prospects for their biological applications. In order to realize the in vivo application of graphene materials and improve the safety of the environment and life system, it is crucial to consider and study on the biodegradation behaviors of graphene. The research on biodegradation of graphene currently mainly focuses on the enzymatic degradation. The degradation behaviors can be tuned by the modification via a series of methods, such as heterogeneous atom doping and surface functionalization, etc. The progress of biodegradation of graphene and their derivatives, especially the enzymatic degradation and their biomedical applications is discussed. The important basis and guidance to further promote the in vivo study of graphene materials will be provided.
Key words： graphene; biocompatibility; enzymatic degradation; surface modification
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