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2020 , Vol. 78 >Issue 9: 901 - 915

DOI: https://doi.org/10.6023/A20050190

综述

近红外二区有机小分子荧光探针

  • 桑若愚 ,
  • 许兴鹏 ,
  • 王其 ,
  • 范曲立 ,
  • 黄维
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  • a 南京邮电大学 有机电子与信息显示国家重点实验室培育基地 信息材料与纳米技术研究院 南京 210023;
    b 东南大学 生物电子学国家重点实验室 南京 210096;
    c 西北工业大学 柔性电子研究院 西安 710072
桑若愚,男,汉族,1996年出生于湖南,2019年本科毕业于河北大学,随后加入南京邮电大学范曲立课题组攻读硕士学位,研究方向为基于NIR-II荧光成像的肿瘤诊疗研究;许兴鹏,男,汉族,1995年出生于安徽,2019年本科毕业于淮北师范大学,随后加入南京邮电大学范曲立课题组攻读硕士学位,研究方向为肿瘤光学诊疗一体化;王其,南京邮电大学副教授,2015年博士毕业于南京大学,同年进入南京邮电大学材料科学与工程学院工作.目前主要从事新型有机小分子NIR-II荧光探针的设计、合成及其在肿瘤诊疗领域的应用研究;范曲立,南京邮电大学教授,2003年于新加坡国立大学获得博士学位,2003年至2006年在复旦大学工作,2006年8月起就职于南京邮电大学.主要研究方向是面向纳米生物医学领域有机半导体材料的制备与临床前的应用研究,近五年来以第一或通讯作者在Nature Communications、Journal of the American Chemical Society、Advanced Materials、ACS Nano等国际期刊发表SCI论文80余篇;承担和参与国家、省部级各类项目10余项,2012年获国家优秀青年科学基金,2013年获国家自然科学二等奖(排名第四),2014年入选国家"百千万人才工程",2019年入选国家"万人计划"中青年科技创新领军人才;黄维,教授,博导,有机电子、塑料电子、印刷电子、生物电子及柔性电子学家,中国科学院院士、俄罗斯科学院外籍院士、亚太材料科学院院士、东盟工程与技术科学院外籍院士、巴基斯坦科学院外籍院士.历任复旦大学先进材料研究院院长,南京邮电大学副校长、党委常委,南京工业大学校长、党委副书记,2017任西北工业大学党委常委、常务副校长.曾两次获得国家自然科学奖二等奖、三次获得高等学校科学研究优秀成果奖(科学技术)自然科学奖一等奖、多次获得江苏省科学技术奖一等奖和二等奖,以及何梁何利基金"科学与技术进步奖".

收稿日期: 2020-05-28

  网络出版日期: 2020-07-15

基金资助

项目受国家自然科学基金（Nos.21602112，21674048）及东南大学生物电子学国家重点实验室开放研究基金资助课题（No.OPSKLB202006）资助.

收起

Near-Infrared-II Fluorescence Probes Based on Organic Small Molecules

  • Sang Ruoyu ,
  • Xu Xingpeng ,
  • Wang Qi ,
  • Fan Quli ,
  • Huang Wei
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  • a Key Laboratory for Organic Electronics and Information Displays, Institute of Advanced Materials, Nanjing University of Posts & Telecommunications, Nanjing 210023, China;
    b State Key Laboratory of Bioelectronics, Southeast University, Nanjing 210096, China;
    c Institute of Flexible Electronics, Northwestern Polytechnical University, Xi'an 710072, China

Received date: 2020-05-28

  Online published: 2020-07-15

Supported by

Project supported by the National Natural Science Foundation of China (Nos. 21602112, 21674048) and the Open Research Fund of State Key Laboratory of Bioelectronics, Southeast University (No. OPSKLB202006).

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摘要

荧光成像凭借灵敏度高、特异性强等诸多优势在重大疾病的诊疗领域发挥着重要作用.然而传统的近红外一区（NIR-I，700~900 nm）荧光成像存在组织穿透性差等问题，限制了其临床应用.近红外二区（NIR-II，1000~1700 nm）荧光成像可以极大地减弱生物组织对光的吸收、散射和自发荧光，从而显著提升成像深度及成像效果.在众多NIR-II荧光探针中，有机小分子由于具有毒性低、代谢快等优点正成为该领域的研究热点.作者以近年来NIR-II有机小分子荧光探针的发展为主体，概括了提升探针荧光量子产率的策略，分别就可激活型、多模态成像型和诊疗一体化型NIR-II荧光探针进行分类讨论，系统介绍了近年来该领域内的研究成果，并针对NIR-II荧光探针未来的发展进行了展望.

关键词： 近红外二区荧光成像; 有机小分子; 可激活探针; 多模态成像; 光学治疗

本文引用格式

桑若愚 , 许兴鹏 , 王其 , 范曲立 , 黄维 . 近红外二区有机小分子荧光探针[J]. 化学学报, 2020 , 78(9) : 901 -915 . DOI: 10.6023/A20050190

Abstract

Fluorescence imaging plays an important role in the diagnosis and treatment of major diseases by virtue of its high sensitivity, strong specificity and excellent spatio-temporal resolution. However, traditional near-infrared-I (NIR-I, 700~900 nm) fluorescence imaging often encounters multiple concerns such as poor tissue penetration, which limits its clinical application. In recent years, near-infrared-II (NIR-II, 1000~1700 nm) fluorescence imaging has been proven to provide better imaging qualities, higher signal-to-noise ratio and deeper tissue penetration than those observed in the NIR-I window due to the diminished photon scattering and tissue auto-fluorescence. Among NIR-II fluorescent probes, organic small molecules are becoming research hotspots in this field due to their advantages of low toxicity, simple structure and fast metabolism. This review describes the recent progress in the design of organic small molecule NIR-II probes and the strategies for improving the fluorescence quantum yield. The application of small molecule NIR-II probes in activatable imaging, multimode imaging and theranostics are evaluated systematically. Current challenges and future perspectives in this emerging field are also prospected.

Key words： near-infrared-II fluorescence imaging; organic small molecules; activatable probe; multimodal imaging; phototherapy

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