基于壳聚糖物理网络的高强韧双网络水凝胶的构建、调控与应用
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杨艳宇, 2017年博士毕业于中国科学院化学研究所, 高分子化学与物理专业, 导师为吴德成研究员, 现为郑州大学副教授, 研究方向为高机械性能水凝胶材料的构筑与功能化研究. |
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王星, 中国科学院化学研究所副研究员, 2014年于中国科学院化学研究所取得博士学位, 研究方向为医用高分子水凝胶的可控制备、功能构筑及应用研究. |
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吴德成, 中国科学院化学研究所研究员、南方科技大学生物医学工程系讲席教授. 研究方向为生物医用高分子、医用敷料/耗材、生物成像、药物输运和组织工程. |
收稿日期: 2020-08-16
网络出版日期: 2020-09-16
基金资助
国家自然科学基金(Nos. 51803188); 国家自然科学基金(51973226); 国家自然科学基金(21725403)
Chitosan-Based High-Mechanical Double-Network Hydrogels: Construction, Modulation and Applications
Received date: 2020-08-16
Online published: 2020-09-16
Supported by
the National Natural Science Foundation of China(Nos. 51803188); the National Natural Science Foundation of China(51973226); the National Natural Science Foundation of China(21725403)
双网络水凝胶由两个具有相反物理性质的交联网络构成, 硬而脆的第一网络在变形过程中断裂耗散能量, 从而增韧凝胶. 当第一网络为具有重建能力的物理网络时, 双网络水凝胶表现出优异的抗软化和机械稳定性. 目前双网络水凝胶第一物理网络类型单一、结构和力学调控繁琐, 因而其开发和应用受到限制. 针对上述问题, 作者发展了硬而脆的壳聚糖物理网络构建的新策略, 壳聚糖的网络类型、结构和物理性质均能简便调控, 然后将其作为第一网络成功地制备了多种高强韧且结构性能可灵活调控的双网络水凝胶, 在抗冻敷料、生物医用、柔性电子和可穿戴设备等领域具有重要的应用价值. 构建壳聚糖基双网络水凝胶的策略操作简单、普适通用, 能够有力促进高强韧水凝胶的开发、功能化及应用.
杨艳宇 , 王星 , 吴德成 . 基于壳聚糖物理网络的高强韧双网络水凝胶的构建、调控与应用[J]. 化学学报, 2021 , 79(1) : 1 -9 . DOI: 10.6023/A20080370
Double-network (DN) hydrogels are composed of two asymmetric networks with contrasting properties, wherein the rigid and brittle network serving as sacrificial bonds effectively dissipates energy to enhance the mechanical performance. The first reconstructable physical network endows the DN hydrogels with outstanding anti-soften and mechanical stability. However, the monotonous type of physical networks and the difficulty in tailoring structure and mechanics greatly limit the development and application of DN hydrogels. Focusing on these problems, we have fabricated the rigid and brittle chitosan physical network with adjustable network type, structure and property and further constructed various chitosan-based DN hydrogels with high mechanical performance and tunable mechanics. The hydrogels were potential materials for anti-freezing dresses, biomedical materials, flexible electronics and wearable devices. The universal strategy of constructing chitosan-based DN hydrogels was beneficial for developing various functional and high-mechanical hydrogels and broadening their applications.
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