共价有机框架的合成及其在肿瘤治疗中的应用研究进展
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王涛, 硕士研究生. 本科毕业于山西大同大学化学与化工学院, 2019年起于山西大同大学化学与化工学院攻读理学硕士学位. 主要研究方向为生物分析化学. |
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白云峰, 博士, 教授, 硕士生导师, 美国普渡大学访问学者, 现任化学生物传感山西省重点实验室副主任. 研究方向为生物分析化学, 近年来, 获得山西省科学技术二等奖1项, 山西省高等学校科学技术二等奖1项, 发表学术论文60余篇, 其中被SCI收录30余篇, 已获授权国家发明专利8项, 实用新型专利7项. |
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冯锋, 博士, 二级教授, 博士生导师, 享受国务院特殊津贴专家, 现任山西大同大学校长. 新世纪百千万人才工程国家级入选者、山西省“三晋英才”支持计划高端领军人才、山西省333人才工程入选者、山西省131领军人才工程学术技术带头人、山西省学术技术带头人、山西省委联系的高级专家、山西省优势特色学科化学学科带头人、山西省功能化学材料重点创新团队带头人、山西省新型介孔材料的合成应用与成果转化工程研究中心负责人、分析化学省重点建设学科带头人、化学生物传感山西省重点实验室主任. 曾获得山西省科学技术二等奖2项、山西省高等学校科学技术一等奖2项、山西省高等学校科学技术二等奖1项、山西省高等学校优秀教学成果特等奖1项、山西省高等学校优秀教学成果二等奖2项. 已出版学术专著2部, 在JACS、Anal Chem、Chem Comm、Biosens Bioelectron等杂志发表学术论文200余篇, 其中被SCI收录论文100余篇, 已获授权国家发明专利20余项, 主持国家自然科学基金4项、省自然科学基金等省级科研项目30余项. |
收稿日期: 2020-12-22
网络出版日期: 2021-02-05
基金资助
项目受国家自然科学基金(21975146); 山西省自然科学基金(201801D121035); 山西省高等学校科学研究优秀成果培育项目(2020KJ023); 山西省省筹资金资助回国留学人员科研项目(2020-133)
Research Progress on the Synthesis of Covalent Organic Frameworks and Their Applications in Tumor Therapy
Received date: 2020-12-22
Online published: 2021-02-05
Supported by
National Natural Science Foundation of China(21975146); Natural Science Foundation of Shanxi Province(201801D121035); Cultivate Scientific Research Excellence Programs of Higher Education Institutions in Shanxi Province(2020KJ023); Shanxi Scholarship Council of China(2020-133)
共价有机框架(covalent organic frameworks, COFs)是近年来开发的一种由有机单元连接而成的高结晶性多孔聚合物, 由于具有良好的孔隙率、模块性、结晶性和生物相容性等特点在肿瘤治疗中显示出了良好的应用前景. 本综述总结了已报道的COFs制备方法, 包括溶剂热合成法、机械化学合成法、微波合成法、离子热合成法、界面合成法、室温合成法和纳米尺度COFs的合成方法, 并根据对肿瘤作用机理的差异, 将用于肿瘤治疗的COFs纳米载药系统归纳为药物化疗、光热治疗、光动力学治疗和联合治疗. 此外还讨论了COFs在肿瘤治疗领域所面临的主要挑战和发展趋势.
王涛 , 赵璐 , 王科伟 , 白云峰 , 冯锋 . 共价有机框架的合成及其在肿瘤治疗中的应用研究进展[J]. 化学学报, 2021 , 79(5) : 600 -613 . DOI: 10.6023/A20120578
Covalent organic frameworks (COFs) are a class of crystalline porous polymer composed of organic units developed in recent years. Due to their good porosity, modularity, crystallinity and biocompatibility, they show a good application prospect in tumor therapy. The porous channels with adjustable pore sizes of COFs make them become an ideal drug delivery material. In addition, COFs can also be used in photothermal therapy and photodynamic therapy in combination with photothermal agents and photosensitizers. This review systematically introduces the synthesis methods of COFs, including solvothermal synthesis, mechanochemical synthesis, microwave synthesis, ionothermal synthesis, interfacial synthesis, room temperature synthesis and nanoscale synthesis. According to the differences in the mechanism of tumor therapy, the applications of COFs nanocarrier system for tumor therapy were reviewed, including chemotherapy, photothermal therapy, photodynamic therapy and combined therapy, proving that the promising drug carrier can effectively improve the therapeutic effect of nanocarriers on tumors. In addition, the main challenges and development trends of the COFs in the field of tumor therapy are discussed. This review could inspire research to design more effective COFs nano-drug delivery systems and promote the development of tumor therapy.
Key words： covalent organic framework; nanomaterial; tumor therapy; drug carrier
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