基于石墨烯独特生物界面效应的功能化载体研究进展
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岳华, 中国科学院过程工程研究所青年研究员. 2012年获中国科学院过程工程研究所博士学位, 研究方向聚焦于纳微粒子生物医药新剂型的理论探索和应用研究. 目前发表SCI论文45篇, 以第一/通讯作者在Nat. Commun.、Sci. Adv.、Adv. Drug Deliver. Rev.等权威期刊发表论文15篇(两篇论文他引超100次), 授权专利4项, 参编书籍2部. 对石墨烯生物学效应的研究工作被评价为“最系统的研究之一”. 被优选为中国科学院青年创新促进会会员, 担任第一届中日颗粒论坛、天然与仿生颗粒论坛学术秘书等. 获中国颗粒学会自然科学奖一等奖(R06)等省部级奖2项. |
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马光辉, 中国科学院过程工程研究所研究员. 国家杰出青年基金(2001)获得者, 1993年在日本东京农工大学获得工学博士学位, 现任生化工程国家重点实验室主任. 主要研究方向为均一生物微球和微囊的制备及其在生化工程中的应用, 研究和开发用于生化分离、药物载体、免疫佐剂(疫苗递送系统)、细胞培养微载体、酶固定化载体等创新产品. 在Nat. Mater.、Nat. Bio. Eng.、Sci. Adv.、Nat. Commun.、Acc. Chem. Res.、JACS、Adv. Mater.等国际著名学术期刊上发表SCI论文431篇, ESI高被引9篇, 总他引超过10000次. 获中国发明专利授权 80余件、美国等国外专利授权12件, 专利技术和产品在国内外500多家单位得到应用. 获国家技术发明二等奖, 北京市科学技术一等奖, 第三世界青年女研究者奖, 中国化工学会基础研究成果一等奖等省部级一等奖多项. |
收稿日期: 2021-06-03
网络出版日期: 2021-08-09
基金资助
北京市自然科学基金面上项目(2202056); 国家自然科学基金重点项目(32030062)
Advances in Functionalized Carriers Based on Graphene's Unique Biological Interface Effect
Received date: 2021-06-03
Online published: 2021-08-09
Supported by
Beijing Municipal Natural Science Foundation(2202056); Key Program of National Natural Science Foundation of China(32030062)
二维石墨烯及其衍生物与生物界面的相互作用, 展现出相比于传统维度粒子截然不同的特性, 为功能化医药载体的设计开发提供了潜力策略. 除了优异的电学、热学、光学等性能外, 石墨烯的独特的二维性质, 可以引起细胞更强的应激反应, 包括与细胞膜发生水平摩擦/竖直嵌入/三明治超级结构、选择性被细胞内吞、胞内限域折叠、引发细胞自噬以及隐形活化效应. 基于上述独特界面效应以及理论模拟机制, 对石墨烯进行合理设计, 可在保障安全性的前提下, 满足药物递送、疫苗佐剂、成像传感、光热治疗等需求. 本综述结合课题组近10年在(氧化)石墨烯与生物界面效应、微观作用机理及应用开发方面的系统研究工作, 同时涵盖了国际最新进展, 以期为石墨烯高效、安全体系的设计、构建和应用, 提供理论依据和前瞻性预测.
岳华 , 马光辉 . 基于石墨烯独特生物界面效应的功能化载体研究进展[J]. 化学学报, 2021 , 79(10) : 1244 -1256 . DOI: 10.6023/A21050238
The interaction of two-dimensional graphene and its derivatives with biological interfaces exhibits distinct properties and advantages over traditional dimensional particles, offering potential strategies for the design and development of functionalized pharmaceutical carriers. Apart from the excellent electrical, thermal and optical properties, the two-dimensional structure endows the graphene stronger interactions with cell membranes and then induces obvious cellular response. These responses include the horizontal friction/slant insertion or sandwiched superstructure, selective internalization by phagocytes, folding effect upon the limited intracellular space, autophagy phenomenon and invisible activation. Based on these unique interfacial effects and theoretical simulation mechanisms, rational designs will meet the needs of drug delivery, vaccine carriers, imaging and sensing, and photothermal therapy as well as good biosafety. This review concludes our researches of exploring the biological interface effects, dynamic molecular mechanism, and applications regarding graphene (oxide) in the past 10 years. Meanwhile, it also covers the latest international progress, in order to provide theoretical basis and prospective prediction for the design, construction, and application of efficient and safe graphene systems.
Key words： graphene; biological interface effect; 2D carrier; drug delivery; vaccine adjuvant
| [1] | Geim, A. K. Science 2009, 324, 1530. |
| [2] | Janegitz, B. C.; Silva, T. A.; Wong, A.; Ribovski, L.; Vicentini, F. C.; Sotomayor, M. D. T.; Fatibello, O. Biosens. Bioelectron. 2017, 89, 224. |
| [3] | Kuok, F. H.; Liao, C. Y.; Wan, T. H.; Yeh, P. W.; Cheng, I. C.; Chen, J. Z. J. Alloys Compd. 2017, 692, 558. |
| [4] | Sun, C. B.; Liu, Y. Q.; Sheng, J. Z.; Huang, Q. K.; Lv, W.; Zhou, G. M.; Cheng, H. M. Mater. Horiz. 2020, 7, 2487. |
| [5] | Chae, H. K.; Siberio-Perez, D. Y.; Kim, J.; Go, Y.; Eddaoudi, M.; Matzger, A. J.; O'keeffe, M.; Yaghi, O. M. Nature 2004, 427, 523. |
| [6] | Chien, C. T.; Li, S. S.; Lai, W. J.; Yeh, Y. C.; Chen, H. A.; Chen, I. S.; Chen, L. C.; Chen, K. H.; Nemoto, T.; Isoda, S.; Chen, M. W.; Fujita, T.; Eda, G.; Yamaguchi, H.; Chhowalla, M.; Chen, C. W. Angew. Chem. Int. Ed. 2012, 51, 6662. |
| [7] | Kurapati, R.; Kostarelos, K.; Prato, M.; Bianco, A. Adv. Mater. 2016, 28, 6052. |
| [8] | Qian, J.; Wang, D.; Cai, F. H.; Xi, W.; Peng, L.; Zhu, Z. F.; He, H.; Hu, M. L.; He, S. L. Angew. Chem. Int. Ed. 2012, 51, 10570. |
| [9] | Robinson, J. T.; Tabakman, S. M.; Liang, Y. Y.; Wang, H. L.; Casalongue, H. S.; Vinh, D.; Dai, H. J. J. Am. Chem. Soc. 2011, 133, 6825. |
| [10] | Chen, D.; Feng, H. B.; Li, J. H. Chem. Rev. 2012, 112, 6027. |
| [11] | Zhao, K. L.; Hao, Y. G.; Zhu, M.; Cheng, G. S. Acta Chim. Sinica 2018, 76, 168. (in Chinese) |
| [11] | (赵克丽, 郝莹, 朱墨, 程国胜, 化学学报, 2018, 76, 168.) |
| [12] | Bullock, C. J.; Bussy, C. Adv. Mater. Interf. 2019, 6, 1900229. |
| [13] | Daneshmandi, L.; Barajaa, M.; Rad, A. T.; Sydlik, S. A.; Laurencin, C. T. Adv. Healthc. Mater. 2020, 2001414. |
| [14] | Yue, H.; Wei, W.; Yue, Z.; Wang, B.; Luo, N.; Gao, Y.; Ma, D.; Ma, G.; Su, Z. Biomaterials 2012, 33, 4013. |
| [15] | Zhang, W. D.; Yan, L.; Li, M.; Zhao, R. S.; Yang, X.; Ji, T. J.; Gu, Z. J.; Yin, J. J.; Gao, X. F.; Nie, G. J. Toxicol. Lett. 2015, 237, 61. |
| [16] | Liao, K. H.; Lin, Y. S.; Macosko, C. W.; Haynes, C. L. ACS Appl. Mater. Inter. 2011, 3, 2607. |
| [17] | Liu, J.; Zhang, D. D.; Lian, S.; Zheng, J. X.; Li, B. F.; Li, T.; Jia, L. Int. J. Nanomed. 2018, 13, 7457. |
| [18] | Hu, W. B.; Peng, C.; Lv, M.; Li, X. M.; Zhang, Y. J.; Chen, N.; Fan, C. H.; Huang, Q. ACS Nano 2011, 5, 3693. |
| [19] | Yang, K.; Wan, J. M.; Zhang, S.; Tian, B.; Zhang, Y. J.; Liu, Z. Biomaterials 2012, 33, 2206. |
| [20] | Ding, Z.; Luo, N.; Yue, H.; Gao, Y.; Ma, G.; Wei, W. J. Mater. Chem. B 2020, 8, 6845. |
| [21] | Yue, H.; Ma, G. H. Acta Polym. Sin. 2020, 51, 125. (in Chinese) |
| [21] | (岳华, 马光辉, 高分子学报, 2020, 51, 125.) |
| [22] | Ma, G. H.; Yue, H. Chin. J. Chem. 2020, 38, 911. |
| [23] | Yue, H.; Wei, W.; Yue, Z.; Lv, P.; Wang, L.; Ma, G.; Su, Z. Eur. J. Pharm. Sci. 2010, 41, 650. |
| [24] | Chen, P.; Yue, H.; Zhai, X.; Huang, Z.; Ma, G. H.; Wei, W.; Yan, L. T. Sci. Adv. 2019, 5, eaaw3192. |
| [25] | Chen, G. Y.; Yang, H. J.; Lu, C. H.; Chao, Y. C.; Hwang, S. M.; Chen, C. L.; Lo, K. W.; Sung, L. Y.; Luo, W. Y.; Tuan, H. Y.; Hu, Y. C. Biomaterials 2012, 33, 6559. |
| [26] | Ma, J.; Liu, R.; Wang, X.; Liu, Q.; Chen, Y.; Valle, R. P.; Zuo, Y. Y.; Xia, T.; Liu, S. ACS Nano 2015, 9, 10498. |
| [27] | Wu, S. Y.; An, S. S. A.; Hulme, J. Int. J. Nanomed. 2015, 10, 9. |
| [28] | Hao, B. J.; Song, T.; Huang, X. Y.; Ye, M.; Qian, W. H. Chin. J. Org. Chem. 2020, 40, 3279. (in Chinese) |
| [28] | (郝冰洁, 宋涛, 黄晓宇, 叶茂, 钱文昊, 有机化学, 2020, 40, 3279.) |
| [29] | Ma, M. H.; Xu, M.; Liu, S. J. Acta Chim. Sinica 2020, 78, 877. (in Chinese) |
| [29] | (马明昊, 徐明, 刘思金, 化学学报, 2020, 78, 877.) |
| [30] | Luo, N.; Ni, D.; Yue, H.; Wei, W.; Ma, G. ACS Appl. Mater. Inter. 2015, 7, 5239. |
| [31] | Luo, N.; Weber, J. K.; Wang, S.; Luan, B.; Yue, H.; Xi, X.; Du, J.; Yang, Z.; Wei, W.; Zhou, R.; Ma, G. Nat. Commun. 2017, 8, 14537. |
| [32] | Ding, Z. W. Ph.D. Dissertation, University of Chinese Academy of Sciences, Beijing, 2020. (in Chinese) |
| [32] | (丁昭文, 博士论文, 中国科学院大学, 北京, 2020.) |
| [33] | Sun, X. T.; Feng, Z. W.; Hou, T. J.; Li, Y. Y. ACS Appl. Mater. Inter. 2014, 6, 7153. |
| [34] | Zuo, G.; Zhou, X.; Huang, Q.; Fang, H. P.; Zhou, R. H. J. Phys. Chem. C 2011, 115, 23323. |
| [35] | Yue, H.; Wei, W.; Gu, Z.; Ni, D.; Luo, N.; Yang, Z.; Zhao, L.; Garate, J. A.; Zhou, R.; Su, Z.; Ma, G. Nanoscale 2015, 7, 19949. |
| [36] | Tu, Y. S.; Lv, M.; Xiu, P.; Huynh, T.; Zhang, M.; Castelli, M.; Liu, Z. R.; Huang, Q.; Fan, C. H.; Fang, H. P.; Zhou, R. H. Nat. Nanotech. 2013, 8, 594. |
| [37] | Duan, G. X.; Kang, S. G.; Tian, X.; Garate, J. A.; Zhao, L.; Ge, C. C.; Zhou, R. H. Nanoscale 2015, 7, 15214. |
| [38] | Zhang, X.; Ding, Z.; Ma, G.; Wei, W. Adv. Sci. 2021, 8, 2004506. |
| [39] | Chen, S. H.; Perez-Aguilar, J. M.; Zhou, R. H. Nanoscale 2020, 12, 7939. |
| [40] | Mao, J.; Guo, R.; Yan, L. T. Biomaterials 2014, 35, 6069. |
| [41] | Yan, L. T.; Yu, X. Nanoscale 2011, 3, 3812. |
| [42] | Shen, H.; Zhang, L. M.; Liu, M.; Zhang, Z. J. Theranostics 2012, 2, 283. |
| [43] | Feng, L. Z.; Liu, Z. A. Nanomedicine 2011, 6, 317. |
| [44] | Nasrollahzadeh, M.; Babaei, F.; Fakhri, P.; Jaleh, B. RSC Adv. 2015, 5, 10782. |
| [45] | Rosenblum, D.; Joshi, N.; Tao, W.; Karp, J. M.; Peer, D. Nat. Commun. 2018, 9, 1410 |
| [46] | Kim, H.; Namgung, R.; Singha, K.; Oh, I. K.; Kim, W. J. Bioconjug. Chem. 2011, 22, 2558. |
| [47] | Cao, W.; He, L.; Cao, W.; Huang, X.; Jia, K.; Dai, J. Acta Biomater. 2020, 112, 14. |
| [48] | Sinha, A.; Cha, B. G.; Choi, Y. J.; Nguyen, T. L.; Yoo, P. J.; Jeong, J. H.; Kim, J. Chem. Mater. 2017, 29, 6883. |
| [49] | Cao, Y. H.; Ma, Y. F.; Zhang, M. X.; Wang, H. M.; Tu, X. L.; Shen, H.; Dai, J. W.; Guo, H. C.; Zhang, Z. J. Adv. Funct. Mater. 2014, 24, 6963. |
| [50] | Meng, C.; Zhi, X.; Li, C.; Li, C.; Chen, Z.; Qiu, X.; Ding, C.; Ma, L.; Lu, H.; Chen, D.; Liu, G.; Cui, D. ACS Nano 2016, 10, 2203. |
| [51] | Xu, L. G.; Xiang, J.; Liu, Y.; Xu, J.; Luo, Y. C.; Feng, L. Z.; Liu, Z.; Peng, R. Nanoscale 2016, 8, 3785. |
| [52] | Zhu, S. J.; Zhang, J. H.; Qiao, C. Y.; Tang, S. J.; Li, Y. F.; Yuan, W. J.; Li, B.; Tian, L.; Liu, F.; Hu, R.; Gao, H. N.; Wei, H. T.; Zhang, H.; Sun, H. C.; Yang, B. Chem. Commun. 2011, 47, 6858. |
| [53] | Wan, J. X.; Chen, X. Y.; Wang, C.; Fang, X. H. J. Func. Mater. 2017, 48, 8024. (in Chinese) |
| [53] | (万吉祥, 陈小源, 王聪, 方小红, 2017, 48, 8024.) |
| [54] | Wu, X.; Tian, F.; Wang, W. X.; Chen, J.; Wu, M.; Zhao, J. X. J. Mater. Chem. C 2013, 1, 4676. |
| [55] | Liu, Z.; Guo, Z.; Zhong, H.; Qin, X.; Wan, M.; Yang, B. Phys. Chem. Chem. Phys. 2013, 15, 2961. |
| [56] | Wang, Y. B.; Kurunthu, D.; Scott, G. W.; Bardeen, C. J. J. Phys. Chem. C 2010, 114, 4153. |
| [57] | Xie, L. M.; Ling, X.; Fang, Y.; Zhang, J.; Liu, Z. F. J. Am. Chem. Soc. 2009, 131, 9890. |
| [58] | Yue, Z.; Lv, P.; Yue, H.; Gao, Y.; Ma, D.; Wei, W.; Ma, G. Chem. Commun. 2013, 49, 3902. |
| [59] | Zhao, H.; Ding, R. H.; Zhao, X.; Li, Y. W.; Qu, L. L.; Pei, H.; Yildirimer, L.; Wu, Z. W.; Zhang, W. X. Drug Disc. Today 2017, 22, 1302. |
| [60] | Mei, Q. S.; Zhang, Z. P. Angew. Chem. Int. Ed. 2012, 51, 5602. |
| [61] | More, M. P.; Deshmukh, P. K. Nanotechnology 2020, 31, 432001. |
| [62] | Kempaiah, R.; Chung, A.; Maheshwari, V. ACS Nano 2011, 5, 6025. |
| [63] | Jiang, W. J.; Mo, F.; Jin, X.; Chen, L.; Xu, L. J.; Guo, L. Q.; Fu, F. F. Adv. Mater. Interf. 2017, 4, 1700425. |
| [64] | Hou, L.; Yan, Y. S.; Tian, C. Y.; Huang, Q. X.; Fu, X. J.; Zhang, Z.; Zhang, H. L.; Zhang, H. J.; Zhang, Z. Z. J. Control. Release 2020, 319, 438. |
| [65] | Shi, X.; Gong, H.; Li, Y.; Wang, C.; Cheng, L.; Liu, Z. Biomaterials 2013, 34, 4786. |
| [66] | Ding, H.; Zhang, F.; Zhao, C. C.; Lv, Y. L.; Ma, G. H.; Wei, W.; Tian, Z. Y. ACS Appl. Mater. Inter. 2017, 9, 27396. |
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