抑郁症相关活性分子的荧光成像★
 |
车飞达, 山东师范大学化学化工与材料科学学院在读博士研究生. 研究方向为抑郁症相关分子的细胞与活体荧光成像. |
 |
赵晓茗, 山东师范大学化学化工与材料科学学院在读硕士研究生. 研究方向为抑郁症相关分子的细胞与活体荧光成像. |
 |
张馨, 在山东师范大学化学化工与材料科学学院在读硕士生. 研究方向为抑郁症相关分子的细胞与活体荧光成像. |
 |
丁琪, 山东师范大学化学化工与材料科学学院在读博士研究生. 研究方向为抑郁症相关分子的细胞与活体荧光成像. |
 |
王昕, 2020年毕业于山东师范大学, 获博士学位. 主要从事抑郁症相关活性分子的细胞与活体荧光成像工作. |
 |
李平, 2008年毕业于山东师范大学, 获博士学位. 1998年加入山东师范大学, 现任化学化工与材料科学学院教授, 国家百千万人才工程入选者、泰山特聘教授、长江学者创新研究带头人. 主要从事新型荧光探针的构建及细胞与活体荧光成像研究工作. |
 |
唐波, 1994年获南开大学博士学位. 同年进入山东师范大学化学化工与材料科学学院担任教授, 为国家杰出青年科学家基金获得者, “973计划”首席科学家. 主要从事分析化学及细胞与活体荧光成像研究工作. |
收稿日期: 2023-04-30
网络出版日期: 2023-06-28
基金资助
国家自然科学基金(22134004); 国家自然科学基金(21927811); 国家自然科学基金(22074083); 及山东省自然科学基金(ZR2020ZD17)
Fluorescence Imaging of Active Molecules Associated with Depression★
Received date: 2023-04-30
Online published: 2023-06-28
Supported by
The National Natural Science Foundation of China(22134004); The National Natural Science Foundation of China(21927811); The National Natural Science Foundation of China(22074083); The Natural Science Foundation of Shandong Province of China(ZR2020ZD17)
抑郁症是抑郁障碍的一种典型情况, 给家庭和社会带来了极大的负担. 目前病因及发病机制的不明确性极大地阻碍了有效抗抑郁药物的开发. 抑郁症相关的活性分子例如活性氧、神经递质及蛋白质等水平变化在抑郁症的发生发展中扮演着关键角色. 因此检测抑郁症相关活性分子对于理解抑郁症的发病机制尤为重要. 荧光成像具有高灵敏度、直观、原位及实时等优点, 因此, 荧光成像技术已经成为监测抑郁症相关活性分子的有效方法. 迄今为止, 研究者们利用荧光成像技术实现了多种抑郁症相关活性分子的成像检测. 综述了近五年抑郁症相关活性分子中的活性氧自由基(ROS), 神经递质和相关酶的荧光成像检测的部分研究进展, 并着重在相关荧光探针的发展方面进行了探讨和展望.
车飞达 , 赵晓茗 , 张馨 , 丁琪 , 王昕 , 李平 , 唐波 . 抑郁症相关活性分子的荧光成像★[J]. 化学学报, 2023 , 81(9) : 1255 -1264 . DOI: 10.6023/A23040191
Depression is a typical condition of depressive disorder, which takes great burden to family and society. However, the current uncertainty about the etiology and pathogenesis has greatly hindered the development of effective antidepressant drugs. Changes in the levels of active molecules associated with depression, such as reactive oxygen species, neurotransmitters and proteins, play a key role in the occurrence and development of depression. Therefore, detection of active molecules related to depression is particularly important for understanding the pathogenesis of depression. Fluorescence imaging has the advantages of high sensitivity, intuition, in situ, real-time, etc. Therefore, fluorescence imaging technology has become an effective method to monitor the active molecules related to depression. Researchers have effectively detected these active molecules using fluorescence imaging. The recent progress in fluorescence imaging detection of reactive oxygen species (ROS), monoamine neurotransmitters and monoamine oxidase in the active molecules associated with depression in the past five years are reviewed with focus on the development of fluorescence probes and prospects.
| [1] | Steven, M.; Edward, P.; Trisha, S.; Emily, C.; Allan, Y.; Rachel, U. The Lancet 2023, 401, 141. |
| [2] | Clark, D. C.; Cavanaugh, S. V.; Gibbons, R. D. J. Nerv. Ment. Dis. 1983, 171, 705. |
| [3] | Miller, A. H.; Haroon, E.; Raison, C. L.; Felger, J. C. Depression Anxiety 2013, 30, 297. |
| [4] | Franklin, T. C.; Xu, C.; Duman, R. S. Brain, Behav., Immun. 2018, 72, 2. |
| [5] | Bhatt, S.; Nagappa, A. N.; Patil, C. R. Drug Discovery Today 2020, 25, 1270. |
| [6] | Maes, M.; Galecki, P.; Chang, Y. S.; Berk, M. Prog. Neuro-Psychopharmacol. Biol. Psychiatry 2011, 35, 676. |
| [7] | Bilici, M.; Efe, H.; K?ro?lu, M. A.; Uydu, H. A.; Bekaro?lu, M.; De?er, O. J. Affective Disord. 2001, 64, 43. |
| [8] | Schildkraut, J. J.; Kety, S. S. Science 1967, 156, 21. |
| [9] | Coppen, A.; Wood, K. M. Acta Psychiatr. Scand. 1980, 61, 21. |
| [10] | Randrup, A.; Br?strup, C. Psychopharmacology 1977, 53, 309. |
| [11] | Janowsky, D.; Davis, J.; El-Yousef, M. K.; Sekerke, H. J. The Lancet 1972, 300, 632. |
| [12] | Heien, M. L. A. V.; Johnson, M. A.; Wightman, R. M. Anal. Chem. 2004, 76, 5697. |
| [13] | Estev?o, M. S.; Carvalho, L. C.; Ferreira, L. M.; Fernandes, E.; Marques, M. M. B. Tetrahedron Lett. 2011, 52, 101. |
| [14] | Ross, A. R. S.; Ambrose, S. J.; Cutler, A. J.; Allan Feurtado, J.; Kermode, A. R.; Nelson, K.; Zhou, R.; Abrams, S. R. Anal. Biochem. 2004, 329, 324. |
| [15] | Duicu, O. M.; Lighezan, R.; Sturza, A.; Balica, R.; Vaduva, A.; Feier, H.; Gaspar, M.; Ionac, A.; Noveanu, L.; Borza, C.; Muntean, D. M.; Mornos, C. Oxid. Med. Cell. Longevity 2016, 8470394. |
| [16] | Meissner, G. W.; Nern, A.; Singer, R. H.; Wong, A. M.; Malkesman, O.; Long, X. Genetics 2018, 211, 473. |
| [17] | Ye, S.; Zhang, H.; Fei, J.; Wolstenholme, C. H.; Zhang, X. Angew. Chem., Int. Ed. 2021, 60, 1339. |
| [18] | Liu, J.; Zhang, W.; Zhou, C.; Li, M.; Wang, X.; Zhang, W.; Liu, Z.; Wu, L.; James, T. D.; Li, P.; Tang, B. J. Am. Chem. Soc. 2022, 144, 13586. |
| [19] | Zhao, Y.; Kim, H. S.; Zou, X.; Huang, L.; Liang, X.; Li, Z.; Kim, J. S.; Lin, W. J. Am. Chem. Soc. 2022, 144, 20854. |
| [20] | Ren, J.-B.; Wang, L.; Guo, R.; Tang, Y.-H.; Zhou, H.-M.; Lin, W.-Y. Acta Chim. Sinica 2021, 79, 87. (in Chinese) |
| [20] | (任江波, 王蕾, 郭锐, 唐永和, 周红梅, 林伟英, 化学学报, 2021, 79, 87.) |
| [21] | Jiang, G.; Lou, X. F.; Zuo, S.; Liu, X.; Ren, T. B.; Wang, L.; Zhang, X. B.; Yuan, L. Angew Chem., Int. Ed. 2023, 62, e202218613. |
| [22] | Li, W.; Yin, S.; Shen, Y.; Li, H.; Yuan, L.; Zhang, X. B. J. Am. Chem. Soc. 2023, 145, 3736. |
| [23] | Wang, X.; Wang, A.-Q.; Qian, M.-R.; Li, B.-X; Jin, L.; Li, T.-H. Chin. J. Anal. Chem. 2023, 4, 531. (in Chinese) |
| [23] | (王雪, 王安琪, 钱美汝, 李滨汐, 金龙, 李胎花, 分析化学, 2023, 4, 531.) |
| [24] | Wang, S.-Q.; Luo, B.-W.; Yu, J.-C.; Gu, Z. Chem. J. Chin. Univ. 2022, 43, 20220577. (in Chinese) |
| [24] | (汪诗琪, 罗博文, 俞计成, 顾臻, 高等学校化学学报, 2022, 43, 20220577.) |
| [25] | Liu, B.-D.; Wang, C.-J.; Qian, Y. Acta Chim. Sinica 2022, 80, 1071. (in Chinese) |
| [25] | (刘巴蒂, 王承俊, 钱鹰, 化学学报, 2022, 80, 1071.) |
| [26] | Xu, N.; Qiao, Q.-L.; Liu, X.-G.; Xu, Z.-C. Acta Chim. Sinica 2022, 80, 553. (in Chinese) |
| [26] | (许宁, 乔庆龙, 刘晓刚, 徐兆超, 化学学报, 2022, 80, 553.) |
| [27] | Zuo, L.; Zhou, T.; Pannell, B. K.; Ziegler, A. C.; Best, T. M. Acta Physiol. 2015, 214, 329. |
| [28] | Zhang, W.; Wang, R.; Liu, W.; Wang, X.; Li, P.; Zhang, W.; Wang, H.; Tang, B. Chem. Sci. 2018, 9, 721. |
| [29] | Schrader, M.; Fahimi, H. D. Biochim. Biophys. Acta, Mol. Cell Res. 2006, 1763, 1755. |
| [30] | Ding, Q.; Tian, Y.; Wang, X.; Li, P.; Su, D.; Wu, C.; Zhang, W.; Tang, B. J. Am. Chem. Soc. 2020, 142, 20735. |
| [31] | Frangioni, J. V. Curr. Opin. Chem. Biol. 2003, 7, 626. |
| [32] | Li, P.; Wang, J.; Wang, X.; Ding, Q.; Bai, X.; Zhang, Y.; Su, D.; Zhang, W.; Zhang, W.; Tang, B. Chem. Sci. 2019, 10, 2805. |
| [33] | Chang, C. C.; Lee, C. T.; Lan, T. H.; Ju, P. C.; Hsieh, Y. H.; Lai, T. J. Psychiatry Res. 2015, 230, 575. |
| [34] | Wang, X.; Li, P.; Ding, Q.; Wu, C.; Zhang, W.; Tang, B. Angew. Chem., Int. Ed. 2019, 58, 4674. |
| [35] | Bienert, G. P.; Schjoerring, J. K.; Jahn, T. P. Biochim. Biophys. Acta 2006, 1758, 994. |
| [36] | Wang, X.; Ding, Q.; Tian, Y.; Wu, W.; Che, F.; Li, P.; Zhang, W.; Zhang, W.; Tang, B. Chem. Commun. 2022, 58, 6320. |
| [37] | Park, H. S.; Kim, S. R.; Lee, Y. C. Respirology 2009, 14, 27. |
| [38] | Zhu, H.; Jia, P.; Wang, X.; Tian, Y.; Liu, C.; Li, X.; Wang, K.; Li, P.; Zhu, B.; Tang, B. Anal. Chem. 2022, 94, 11783. |
| [39] | Mohammad, L. F.; Moses, L.; Gwaltney, S. M. J. Vet. Pharmacol. Ther. 2008, 31, 187. |
| [40] | Unger, E. K.; Keller, J. P.; Altermatt, M.; Liang, R.; Matsui, A.; Dong, C.; Hon, O. J.; Yao, Z.; Sun, J.; Banala, S.; Flanigan, M. E.; Jaffe, D. A.; Hartanto, S.; Carlen, J.; Mizuno, G. O.; Borden, P. M.; Shivange, A. V.; Cameron, L. P.; Sinning, S.; Underhill, S. M.; Olson, D. E.; Amara, S. G.; Temple, L. D.; Rudnick, G.; Marvin, J. S.; Lavis, L. D.; Lester, H. A.; Alvarez, V. A.; Fisher, A. J.; Prescher, J. A.; Kash, T. L.; Yarov-Yarovoy, V.; Gradinaru, V.; Looger, L. L.; Tian, L. Cell 2020, 183, 1986. |
| [41] | Wan, J.; Peng, W.; Li, X.; Qian, T.; Song, K.; Zeng, J.; Deng, F.; Hao, S.; Feng, J.; Zhang, P.; Zhang, Y.; Zou, J.; Pan, S.; Shin, M.; Venton, B. J.; Zhu, J. J.; Jing, M.; Xu, M.; Li, Y. Nat. Neurosci. 2021, 24, 746. |
| [42] | Dinarvand, M.; Neubert, E.; Meyer, D.; Selvaggio, G.; Mann, F. A.; Erpenbeck, L.; Kruss, S. Nano Lett. 2019, 19, 6604. |
| [43] | Berke, J. D. Nat. Neurosci. 2018, 21, 787. |
| [44] | Liu, Y.; Li, W.; Wu, P.; Ma, C.; Wu, X.; Xu, M.; Luo, S.; Xu, Z.; Liu, S. Sens. Actuators, B 2019, 281, 34. |
| [45] | Alizadeh, N.; Salimi, A. Anal. Chim. Acta 2019, 1091, 40. |
| [46] | An, J.; Chen, M.; Hu, N.; Hu, Y.; Chen, R.; Lyu, Y.; Guo, W.; Li, L.; Liu, Y. Spectrochim. Acta, Part A 2020, 243, 118804. |
| [47] | Lin, H.; Huang, J.; Ding, L. J. Nanomater. 2019, 1. |
| [48] | Naik, V.; Zantye, P.; Gunjal, D.; Gore, A.; Anbhule, P.; Kowshik, M.; Bhosale, S. V.; Kolekar, G. ACS Appl. Bio Mater. 2019, 2, 2069. |
| [49] | Sangubotla, R.; Kim, J. Mater. Sci. Eng., C 2021, 122, 111916. |
| [50] | Patriarchi, T.; Mohebi, A.; Sun, J.; Marley, A.; Liang, R.; Dong, C.; Puhger, K.; Mizuno, G. O.; Davis, C. M.; Wiltgen, B.; von Zastrow, M.; Berke, J. D.; Tian, L. Nat. Methods 2020, 17, 1147. |
| [51] | Sun, F.; Zhou, J.; Dai, B.; Qian, T.; Zeng, J.; Li, X.; Zhuo, Y.; Zhang, Y.; Wang, Y.; Qian, C.; Tan, K.; Feng, J.; Dong, H.; Lin, D.; Cui, G.; Li, Y. Nat. Methods 2020, 17, 1156. |
| [52] | Zhou, N.; Huo, F.; Yue, Y.; Yin, C. J. Am. Chem. Soc. 2020, 142, 17751. |
| [53] | Zhou, N.; Yin, C.; Yue, Y.; Huo, F. Sens. Actuators, B 2022, 373. |
| [54] | Zhou, N.; Yin, C.; Yue, Y.; Zhang, Y.; Cheng, F.; Huo, F. Chem. Commun. 2022, 58, 2999. |
| [55] | Zuo, Z.; Kang, T.; Hu, S.; Su, W.; Gan, Y.; Miao, Z.; Zhao, H.; Feng, P.; Ke, B.; Li, M. Anal. Chem. 2022, 94, 6441. |
| [56] | Zhang, L.; Liu, X. A.; Gillis, K. D.; Glass, T. E. Angew. Chem., Int. Ed. 2019, 58, 7611. |
| [57] | Yan, H.; Wang, Y.; Huo, F.; Yin, C. J. Am. Chem. Soc. 2023, 145, 3229. |
| [58] | Feng, J.; Zhang, C.; Lischinsky, J. E.; Jing, M.; Zhou, J.; Wang, H.; Zhang, Y.; Dong, A.; Wu, Z.; Wu, H.; Chen, W.; Zhang, P.; Zou, J.; Hires, S. A.; Zhu, J. J.; Cui, G.; Lin, D.; Du, J.; Li, Y. Neuron 2019, 102, 745. |
| [59] | Qiao, J.; Wu, D.; Song, Y.; Ji, W.; Yue, Q.; Mao, L.; Qi, L. Anal. Chem. 2021, 93, 14743. |
| [60] | Youdim, M. B. H.; Edmondson, D.; Tipton, K. F. Nat. Rev. Neurosci. 2006, 7, 295. |
| [61] | Shulman, K. I.; Herrmann, N.; Walker, S. E. CNS Drugs 2013, 27, 789. |
| [62] | Zhang, S.; Zhao, B.; Yu, L.; Liu, J.; Zhang, X. Talanta 2020, 209, 120559. |
| [63] | Duangkamol, C.; Wangngae, S.; Wet-Osot, S.; Khaikate, O.; Chansaenpak, K.; Lai, R. Y.; Kamkaew, A. Molecules 2023, 28. |
| [64] | Dong, J.; Zhang, C.; Zhao, B.; Zhang, X.; Leng, Z.; Liu, J. Dyes Pigm. 2020, 174. |
| [65] | Meng, Z.; Yang, L.; Yao, C.; Li, H.; Fu, Y.; Wang, K.; Qu, Z.; Wang, Z. Dyes Pigm. 2020, 176. |
| [66] | Mei, Y.; Liu, Z.; Liu, M.; Gong, J.; He, X.; Zhang, Q. W.; Tian, Y. Chem. Commun. 2022, 58, 6657. |
| [67] | Walczak-Nowicka, ?. J.; Herbet, M. Int. J. Mol. Sci. 2021, 22, 9290. |
| [68] | Wang, X.; Li, P.; Ding, Q.; Wu, C. C.; Zhang, W.; Tang, B. J. Am. Chem. Soc. 2019, 141, 2061. |
| [69] | Fortibui, M. M.; Jang, M.; Lee, S.; Ryoo, I. J.; Ahn, J. S.; Ko, S. K.; Kim, J. ACS Appl. Bio Mater. 2022, 5, 2232. |
/
| 〈 |
|
〉 |
