肿瘤特异性多肽探针及其在生物成像中的应用
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王博, 兰州大学化学化工学院在读硕士生, 2020年6月于西安交通大学化学工程与工艺专业获得学士学位, 随后加入兰州大学化学化工学院肖建喜教授课题组, 主要研究方向为多肽探针的设计及其在肿瘤检测方面的应用. |
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蔡向东, 博士, 分别于2015年和2021年在兰州大学化学化工学院化学专业获得学士学位和博士学位, 随后在兰州大学生命科学学院从事博士后研究工作. 主要研究方向为基于多肽化学的肿瘤诊断和治疗. |
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肖建喜, 教授, 博士生导师. 2003年获武汉大学化学学士学位, 2009年获美国新泽西州罗格斯大学(Rutgers-New Brunswick)化学博士学位. 2009~2011年在罗格斯大学从事博士后研究工作. 2012年获聘为兰州大学教授. 主要研究领域包括生物分析化学, 生物医用材料和蛋白质工程与产业化应用等. 已发表多篇SCI期刊论文, 申请发明专利40余项. |
收稿日期: 2023-10-13
网络出版日期: 2024-02-02
基金资助
国家自然科学基金(22074057); 甘肃省自然科学基金(20YF3FA025); 甘肃省自然科学基金(23JRRA1096); 中国博士后科学基金(2022M711449)
Tumor-specific Peptide Probes and the Applications in Bioimaging
Received date: 2023-10-13
Online published: 2024-02-02
Supported by
National Natural Science Foundation of China(22074057); Natural Science Foundation of Gansu Province(20YF3FA025); Natural Science Foundation of Gansu Province(23JRRA1096); China Postdoctoral Science Foundation(2022M711449)
肿瘤是由细胞、细胞外基质及微环境等多因素组成的复杂系统, 不同因素在肿瘤的发生和发展中发挥关键作用. 肿瘤细胞、细胞外基质及微环境的特异性分析对于肿瘤的精准诊断和靶向治疗至关重要. 多肽探针具有特异性高、生物相容性好、组织穿透能力强和易于制备等优点, 已被广泛用于肿瘤的特异性成像研究. 本文综述了多肽探针对肿瘤细胞、免疫细胞等细胞靶点的特异性成像; 并介绍了以胶原蛋白、纤维蛋白等外基质蛋白为靶点的肿瘤特异性多肽探针的成像研究. 本文还总结了对肿瘤微环境中弱酸性、高酶活性等因素响应的肿瘤特异性多肽探针及其生物成像应用. 最后, 本文总结并讨论了肿瘤特异性多肽探针所面临的挑战与机遇, 展望了其在肿瘤精准诊断和个性化治疗领域的前景.
王博 , 蔡向东 , 肖建喜 . 肿瘤特异性多肽探针及其在生物成像中的应用[J]. 化学学报, 2024 , 82(3) : 367 -376 . DOI: 10.6023/A23100448
The tumor is a complex system composed of various elements, encompassing cells, extracellular matrix, and the tumor microenvironment. Each of these distinct factors plays a pivotal role in the development and progression of tumors. The specific analysis of tumor-associated cells, extracellular matrix, and tumor microenvironment is of paramount importance for precise diagnosis and targeted therapy of tumors. Peptide probes have gained substantial prominence in investigations focused on tumor-specific imaging, primarily attributed to their notable attributes, including high specificity, biocompatibility, tissue-penetrating capabilities, and straightforward preparation processes. This review comprehensively summarizes the peptide probes for specific imaging of tumor-associated cells. The specific recognition of cells was by binding various cellular markers, such as the epidermal growth factor receptor (EGFR), vascular endothelial growth factor receptor (VEGFR), and folate receptor (FRα) for tumor cells. Additionally, the biomarkers include CD206, neurokinin-1 receptor (NK-1R), and CD11c for immune cells, along with nucleolin and integrins for tumor vascular endothelial cells. Furthermore, this comprehensive review encapsulates peptide probes designed for the specific targeting of extracellular matrix proteins and their applications in tumor-specific imaging. The focal points among these protein targets encompass pathological collagen, matrix metalloproteinases, and fibronectin. Of particular significance is the potential of pathological collagen as a highly promising extracellular matrix target for achieving tumor-specific imaging. The review comprehensively outlines tumor-specific peptide probes responsive to various factors within the tumor microenvironment. Commonly encountered responsive factors in the tumor microenvironment include mild acidity (pH), heightened enzyme activity, such as matrix metalloproteinases and cathepsin, and elevated levels of oxidative stress. It further explores their versatile applications in bioimaging. Lastly, this review discusses the clinical applications of tumor-specific peptide probes in diagnostic practices. It explores the current challenges and prospects of these peptide probes, elucidating their potential contributions to precision diagnosis and personalized treatment of tumors, including precise surgical navigation and their synergistic use with immunotherapy.
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