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2026 26070265

DOI: https://doi.org/10.6023/A26070265

综述

金属-有机小分子协同不对称催化研究进展★

  • 刘云龙 ,
  • 丁天琦 ,
  • 许子涵 ,
  • 贾香清 ,
  • 徐政虎
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  • a山东大学化学与化工学院 山东省济南市山大南路27号 250100;
    b海南大学化学与化工学院 海南省海口市人民大道58号 570228
刘云龙, 2000年生于山东省临沂市, 2022年本科毕业于山东师范大学, 现为山东大学化学与化工学院有机化学专业博士研究生, 主要研究课题为不对称催化;丁天琦, 2002年生于山东省济宁市,2020年本科毕业于山东师范大学, 现为山东大学化学与化工学院有机化学专业硕士研究生, 主要研究课题为不对称催化;许子涵, 2004年生于山东省泰安市, 2026年本科毕业于山东大学化学与化工学院, 现为山东大学化学与化工学院化学专业硕士研究生, 主要研究课题为平面手性环芳骨架构建;贾香清, 山东大学化学与化工学院副研究员. 2016年博士毕业于中国科学院上海有机所, 之后在德国维尔茨堡大学和美国得克萨斯大学达拉斯分校从事博士后研究, 2025年加入山东大学. 研究工作集中于惰性化学键的选择性断裂与不对称重组;徐政虎, 海南大学、山东大学教授.2001 年本科毕业于南京大学, 2007年博士毕业于中国科学院上海有机所, 2007年至2010年, 在美国迈阿密大学从事博士后研究. 2011年入职山东大学化学与化工学院, 2026年加入海南大学工作. 一直致力于绿色, 经济, 高效的有机合成反应的研究, 发展了 "串联金属接力催化" 的合成方法学, 广泛应用于复杂手性环系有机分子的合成. ★“不对称协同催化”专辑

收稿日期: 2026-07-25

  网络出版日期: 2026-09-14

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Recent Advances in Metal-Organo Cooperative Asymmetric Catalysis

  • Liu Yunlong ,
  • Ding Tianqi ,
  • Xu Zihan ,
  • Jia Xiangqing ,
  • Xu Zhenghu
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  • aDepartment of Chemistry, Shandong University, Jinan, 250100, China.;
    aSchool of Chemistry and Chemical Engineering, Hainan University, Haikou 570228, China

Received date: 2026-07-25

  Online published: 2026-09-14

Supported by

Natural Science Foundation of China (22471143) and Taishan Scholar award of Shandong Province.

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摘要

不对称催化是制备精细化学品与手性药物分子的关键技术, 但单一过渡金属催化、有机小分子催化各自存在固有局限. 金属-有机小分子协同不对称催化结合两类催化剂优势, 通过协同活化与双重立体调控打破单一体系瓶颈, 可高效实现多键活化、复杂手性骨架合成与立体发散转化, 是不对称催化领域的前沿热点. 本文根据有机小分子催化剂种类系统综述2022年以来年来金属-有机小分子协同不对称催化领域的最新进展, 重点聚焦手性磷酸、硫脲和方酰胺等氢键供体、手性胺类等经典有机小分子与铑、金、钯、铜等过渡金属的协同催化体系, 总结该策略在各类反应中的应用, 并结合有机合成发展趋势, 展望该领域的发展前景, 旨在为新型高效、高立体选择性协同催化体系的设计与开发提供理论参考.

关键词： 过渡金属; 有机催化; 协同催化; 不对称催化

本文引用格式

刘云龙 , 丁天琦 , 许子涵 , 贾香清 , 徐政虎 . 金属-有机小分子协同不对称催化研究进展★[J]. 化学学报, 2026 : 26070265 . DOI: 10.6023/A26070265

Abstract

Asymmetric catalysis serves as a core and pivotal technology for the precise synthesis of high-value fine chemicals and chiral pharmaceutical molecules, laying an essential foundation for modern organic synthesis and pharmaceutical industrial development. Nevertheless, traditional monometallic transition-metal catalysis and independent organocatalysis each suffer from inherent and unavoidable limitations in practical applications. Single transition-metal catalysis often faces challenges of insufficient stereocontrol ability and harsh reaction conditions, while pure organocatalysis is usually restricted by low catalytic activity and narrow reaction substrate scope. Merging the respective merits of the two catalytic modes, cooperative metal-organocatalytic asymmetric catalysis effectively overcomes the key bottlenecks of single catalytic systems through mutual synergistic activation and dual stereocontrol regulation. This advanced catalytic strategy enables efficient multi-bond activation, precise construction of structurally complex chiral skeletons and flexible stereodivergent transformations, thus standing as a vital cutting-edge research frontier in modern asymmetric catalysis. Herein, we systematically review the latest research advances in cooperative metal-organocatalytic asymmetric catalysis since 2022, classified by different types of organocatalysts. We focus on high-efficiency cooperative catalytic systems integrating classic chiral organocatalysts and common transition metals, including chiral phosphoric acids, hydrogen-bond donors (thioureas and squaramides), chiral amines, isothioureas, N-heterocyclic carbenes (NHCs), as well as rhodium, gold, palladium and copper catalysts. We comprehensively summarize the versatile applications of this dual catalytic strategy in various asymmetric synthesis reactions. Combined with the developmental trends and application demands of modern organic synthesis, we also outline the future development prospects of this research field. This review aims to provide reliable theoretical references for the rational design and further exploitation of novel cooperative catalytic systems with high catalytic efficiency and excellent stereoselectivity.

Key words： transition metals; organocatalysis; cooperative catalysis; asymmetric catalysis

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