Structure, Antibacterial Activities and DNA Cleavage of a Copper(II) Complex with 2-(2'-Pyridyl)benzimidazole and L-Alaninate

doi:10.6023/A1110252

Acta Chimica Sinica ›› 2012, Vol. 70 ›› Issue (08): 973-979.DOI: 10.6023/A1110252 Previous Articles Next Articles

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(2-(2'-吡啶)苯并咪唑)(L-丙氨酸根)铜(II)配合物结构、抗菌活性及DNA断裂作用

卢艳梅^a, 区志镔^a, 胡伟^a, 乐学义^a,b

a 华南农业大学理学院应用化学系广州 510642;
b 华南农业大学生物材料研究所广州 510642

投稿日期:2011-10-25 修回日期:2012-01-03 发布日期:2012-01-20
通讯作者: 乐学义 E-mail:lexy@ scau.edu.cn
基金资助:
广东省科技计划项目(No. 2009B020312010)及华南农业大学211 工程重点项目(No. 2009B 010100001)资助项目.

Structure, Antibacterial Activities and DNA Cleavage of a Copper(II) Complex with 2-(2'-Pyridyl)benzimidazole and L-Alaninate

Lu Yanmei^a, Ou Zhibin^a, Hu Wei^a, Le Xueyi^a,b

a Department of Applied Chemistry, South China Agricultural University, Guangzhou 510642;
b Institue of Biomaterial, South China Agricultural University, Guangzhou 510642

Received:2011-10-25 Revised:2012-01-03 Published:2012-01-20
Supported by:
Project supported by the Program of Guangdong Provincial Science and Technology (No. 2009B020312010) and 211 Project Program Foundation of South China Agricultural University (No. 2009B010100001).

A new copper(II) complex: [Cu(HPB)(L-Ala)(ClO₄)(H₂O)]₂·H₂O [HPB ＝ 2-(2'-pyridyl) benzimidazole, L-Ala＝L-alaninate], was synthesized and characterized by elemental analysis, IR, UV-Vis, molar conductivity, ES-MS and single crystal X-ray diffraction. The crystal belongs to the monoclinic space group P2₁, with the crystal cell parameters: a＝1.1900(2) nm, b＝0.80500(16) nm, c＝1.9700(4) nm, β＝ 94.78(3)°, Z＝2, D_c＝1.672 g·cm^-3, F(000)＝968, residual factors R₁＝0.0427, wR₂＝0.1106 [I>2σ(I)], S ＝0.999. The central Cu(II) ions for the complex show a distorted and elongated octahedral geometry in which two nitrogens of HPB and the carboxylate oxygen atom O and the amino nitrogen atom N of L-Ala bind at the molecular plane, a water molecule and one oxygen atom of perchlorate are coordinated at the axial site. The complex was tested for its ability to inhibit the growth of two gram-positive (B. subtilis, S. aureus) and two gram-negative (E. coil, Salmonella) bacteria by doubling dilutions method, and DNA interaction of the complex has been studied. The result showed that the MICs of the complex against the bacteria are in the range of 50～80 μg·mL^-1, and can cleave pBR 322 DNA in the presence of vitamin C with hydroxyl radicals as the active species.

Key words: 2-(2’-pyridyl)benzimidazole, L-alanine, copper(II) complex, crystal structure, antibacterial activity, pBR322 DNA

Cite this article

Lu Yanmei, Ou Zhibin, Hu Wei, Le Xueyi. Structure, Antibacterial Activities and DNA Cleavage of a Copper(II) Complex with 2-(2'-Pyridyl)benzimidazole and L-Alaninate[J]. Acta Chimica Sinica, 2012, 70(08): 973-979.

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(2-(2'-吡啶)苯并咪唑)(L-丙氨酸根)铜(II)配合物结构、抗菌活性及DNA断裂作用

Structure, Antibacterial Activities and DNA Cleavage of a Copper(II) Complex with 2-(2'-Pyridyl)benzimidazole and L-Alaninate

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