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Acta Chimica Sinica ›› 1962, Vol. 28 ›› Issue (3): 173-180. Previous Articles Next Articles
任雲峰, 高怡生
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JEN YUN-FENG, KAO YEE-SHENG
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In the present investigation the synthesis of p-[bis-(2-chloroethyl)aminomethyl]-phenyl-alanine dihydrochloride (IIIa, designated as AT-290) has been described.As can be seen from the structure, it is derived from the nitrogen mustard HN2(Ⅳ R=H) by substituting one hydrogen atom of the methyl group with the p-phenylalanine moiety.Since the para position of the benzene ring is of importance in a number of metabolic functions of phenylalanine, the meta-and oTtho-isomer of Ⅲa, namely,m-[bis-(2-chloroethyl)amino-methyl]-phenylalanine dihydrochloride (Ⅲb, AT-582) and o-(bis-(2-chloroethyl)aminome-thyl]-phenylalanine dihydrochloride (Ⅲc, AT-581) were also synthesized.
JEN YUN-FENG, KAO YEE-SHENG. TUMOUR CHEMOTHERAPY Ⅶ. SYNTHESIS OF ρ-,m-and o-[BIS-(2-CHLOROETHYL)-AMINOMETHYL]-PHENYLALANINE DIHYDROCHLORIDE[J]. Acta Chimica Sinica, 1962, 28(3): 173-180.
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