Acta Chimica Sinica ›› 1980, Vol. 38 ›› Issue (6): 567-572. Previous Articles     Next Articles

关于傣肌松的结构

陈仲良   

  1. 中国科学院上海药物研究所
  • 投稿日期:1978-12-08 发布日期:2013-06-03

ON THE STRUCTURE OF DAIJISONG

CHEN ZHONG-LIANG   

  1. Shanghai Institute of Materia Medica, Academia Sinica
  • Received:1978-12-08 Published:2013-06-03

The major alkaloid of Cissampedos parezra L,was first isolated by the Yunnan Pharmaceutical Institute.Its methiodide has been used clinically as muscular relaxant with a trade name as "Daijisong".On treatment with ethyl iodide,this alkaloid gave a diethiodide,which after exhaustive Hofmann degradation (twice) yielded a N-free substanc),identified as diethylbebeerilene.This compound was identical with the product from tubocurarine under similar treament.On direct comparison,the dimethyl ethor dimethiodide of this alkaloid was identical with a mixture of equal amounts of d and l O,O-dimthylourine dimethiodide.It is thus ooniirmed that Daijsong is the methiodide of dl-curine.