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Acta Chimica Sinica ›› 1981, Vol. 39 ›› Issue (4): 358-361. Previous Articles Next Articles
刘志煜, 韩卫平
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LIU ZEI-Yu, HAN WEI-PING
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An alternative synthesis of the title compound (1) is reported. Reaction of ethyl: 8-(chloroformyl)-octanoate(4)with the Grignard reagent of 2-(2'-bromoethyl)-1, 3-diogane (3) gave compound 5. The latter was hydrolyzed in formic acid followed by alkaline cyclization and esterification to give compound 1 in 57% yield. Minor improvement in the preparation of compound 3 was also realized.
LIU ZEI-Yu, HAN WEI-PING. THE SYNTHESIS OF A PROSTAGLANDIN INTERMEDIATE 2-(6’-METHOXYCARBONYLHEXYL)-CYCLOPENT-2-EN-1-ONE[J]. Acta Chimica Sinica, 1981, 39(4): 358-361.
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