Study on biologically active coordination compounds of metal ions III: Synthesis, characterization and antitumor activity of rare earths citrate complexes of 3,6-bis(dimethylamino)-dibenzopyriodonium

Acta Chimica Sinica ›› 1989, Vol. 47 ›› Issue (4): 328-332. Previous Articles Next Articles

Original Articles

具有生物活性的金属配合物的研究 III: 3-6(二(二甲氨基)-二苯并碘六环稀土二柠檬酸配合物的合成, 性质及抗肿瘤活性

陈淑英;王初华;侯自杰;李笃;刘力生;宋家玉

兰州大学化学系;兰州大学生物系

发布日期:1989-04-15

Study on biologically active coordination compounds of metal ions III: Synthesis, characterization and antitumor activity of rare earths citrate complexes of 3,6-bis(dimethylamino)-dibenzopyriodonium

CHEN SHUYING;WANG CHUHUA;HOU ZIJIE;LI DU;LIU LISHENG;SONG JIAYU

Published:1989-04-15

Abstract

L3[LnQ2].nH2O (L+ = 3,6-bis(dimethylamino)benzopyriodonium; H3Q = citric acid; Ln = La-Nd, n = 5; Ln = Sm-Tb, n = 4; Ln = Dy-Lu, Y, n = 3) were prepared The complexes were characterized by x-ray powder diffraction, TG-DTA, molar conductances, IR, UV and 1H NMR. Inhibiting effect of La complex on incorporation of 3H-TdR into DNA of leukemia (L7712) cells in vitro was observed The results show that La complex is more effective than its precursors.

Key words: ULTRAVIOLET SPECTROPHOTOMETRY, BIOLOGICAL ACTIVITY, ANTICARCINOGEN, INFRARED SPECTROPHOTOMETRY, X-RAY DIFFRACTION ANALYSIS, BENZENE P, CITRIC ACID, RARE EARTH METAL COMPLEX, CERIUM COMPLEX, DIFFERENTIAL THERMAL ANALYSIS

CLC Number:

O627
R914

Cite this article

CHEN SHUYING;WANG CHUHUA;HOU ZIJIE;LI DU;LIU LISHENG;SONG JIAYU. Study on biologically active coordination compounds of metal ions III: Synthesis, characterization and antitumor activity of rare earths citrate complexes of 3,6-bis(dimethylamino)-dibenzopyriodonium[J]. Acta Chimica Sinica, 1989, 47(4): 328-332.

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具有生物活性的金属配合物的研究 III: 3-6(二(二甲氨基)-二苯并碘六环稀土二柠檬酸配合物的合成, 性质及抗肿瘤活性

Study on biologically active coordination compounds of metal ions III: Synthesis, characterization and antitumor activity of rare earths citrate complexes of 3,6-bis(dimethylamino)-dibenzopyriodonium

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