Study on biologically active coordination compounds of metal ions II: Synthesis, characterization and antitumor activity of rare earth EDTA complexes of 3,6-bis(dimethylamino)-dibenzopyridonium

Acta Chimica Sinica ›› 1989, Vol. 47 ›› Issue (4): 322-327. Previous Articles Next Articles

Original Articles

具有生物活性的金属配合物的研究 II: 3,6-二(二甲氨基)-二苯并碘六环稀土乙二胺四乙酸配合物的合成, 性质及抗肿瘤活性

陈淑英;王初华;王欣;侯自杰;李笃;刘力生;宋家玉

兰州大学化学系;兰州大学生物系

发布日期:1989-04-15

Study on biologically active coordination compounds of metal ions II: Synthesis, characterization and antitumor activity of rare earth EDTA complexes of 3,6-bis(dimethylamino)-dibenzopyridonium

CHEN SHUYING;WANG CHUHUA;WANG XIN;HOU ZIJIE;LI DU;LIU LISHENG;SONG JIAYU

Published:1989-04-15

Abstract

Q[LnL].xH2O (Q+ = 3,6-bis(dimethylamino)dibenzopyriodonium; H4L = EDTA; Ln = Ce, x = 2; Ln = Pr, x = 3; Ln = Nd-Lu, Y, x = 4) were prepared The complexes were characterized by TG-DTA, x-ray powder diffraction, molar conductance, UV and IR spectra. The inhibiting effect of each complex on incorporation of 3H-TdR into DNA of leukemia (L7712) cells in vitro was observed The results show that they are all more effective than their precursors.

Key words: ULTRAVIOLET SPECTROPHOTOMETRY, BIOLOGICAL ACTIVITY, ANTICARCINOGEN, INFRARED SPECTROPHOTOMETRY, X-RAY DIFFRACTION ANALYSIS, BENZENE P, CITRIC ACID, EDTA P, RARE EARTH METAL COMPLEX, METAL COMPLEX

CLC Number:

O627
R914

Cite this article

CHEN SHUYING;WANG CHUHUA;WANG XIN;HOU ZIJIE;LI DU;LIU LISHENG;SONG JIAYU. Study on biologically active coordination compounds of metal ions II: Synthesis, characterization and antitumor activity of rare earth EDTA complexes of 3,6-bis(dimethylamino)-dibenzopyridonium[J]. Acta Chimica Sinica, 1989, 47(4): 322-327.

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具有生物活性的金属配合物的研究 II: 3,6-二(二甲氨基)-二苯并碘六环稀土乙二胺四乙酸配合物的合成, 性质及抗肿瘤活性

Study on biologically active coordination compounds of metal ions II: Synthesis, characterization and antitumor activity of rare earth EDTA complexes of 3,6-bis(dimethylamino)-dibenzopyridonium

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