Acta Chimica Sinica ›› 1993, Vol. 51 ›› Issue (1): 85-89. Previous Articles     Next Articles

Original Articles

催化转移氢化还原腈类化合物成胺

尤冬;周后元;王其灼   

  1. 中国药科大学药物化学研究室;国家医药管理局上海医药工业研究院
  • 发布日期:1993-01-15

Reduction of nitriles to amines by catalytic transfer hydrogenation

YOU DONG;ZHOU HOUYUAN;WANG QIZHUO   

  • Published:1993-01-15

A simple and convenient method for reduction of nitriles to amines was reported .in the presence of solium hydroxide, nickel chloride (NiCl2.6H2O) was reduced by hydrazine hydrate to deposit active nickle metal which , in turn , catalyzed the hydrogen transfer from hydrazine hydrate to nitriles, thus affording amines in moderate yields(35~82%). but the poor yieldsof amines (12~175)from α, β-unsaturated nitriles were obtained.

Key words: AMINES, REDUCTION, REDUCTION REACTION, NITRILE, HYDRAZINE HYDRATE, NICKEL CHLORIDE, CATALYTIC REACTION

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