Synthesis of bis-oxazolines and the application in asymmetic cyclopropanation

Acta Chimica Sinica ›› 1994, Vol. 52 ›› Issue (12): 1218-1220. Previous Articles

Original Articles

二取双恶唑啉衍生物的合成及其在不对称环丙烷化反应中的应用

杨智才;钟民;陈良

华东师范大学化学系

发布日期:1994-12-15

Synthesis of bis-oxazolines and the application in asymmetic cyclopropanation

YANG ZHICAI;ZHONG MIN;CHEN LIANG

Published:1994-12-15

Abstract

Bisoxazolines I (R1, R2 = PhCH2, H; Ph3COCH2, 4-O2NC6H4; HOCH2, 4-O2NC6H4) were easily prepared from di-Et propanediimidoate dihydrochloride and chiral amino alcs. R1CH(NH2)CH(OH)R2. These bisoxazolines were successfully applied to the reaction of alkyl diazoacetate with olefin to give optically active alkyl cyclopropanecarboxylate. The highest enantioselectivity achieved 95% d.e. in the catalytic cyclopropanation of isobutene

Key words: ALKENE, CYCLOPROPANE P, CYCLIZATION, AMINO ALCOHOL

CLC Number:

O621

Cite this article

YANG ZHICAI;ZHONG MIN;CHEN LIANG. Synthesis of bis-oxazolines and the application in asymmetic cyclopropanation[J]. Acta Chimica Sinica, 1994, 52(12): 1218-1220.

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二取双恶唑啉衍生物的合成及其在不对称环丙烷化反应中的应用

Synthesis of bis-oxazolines and the application in asymmetic cyclopropanation

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