Acta Chimica Sinica ›› 1994, Vol. 52 ›› Issue (4): 412-416. Previous Articles    

Original Articles

1,2,4-三嗪类化合物的研究XXI.3-甲硫基-5-氧代-2.5-二氧-1,2,4-三嗪的取代苯磺铣化反应及6- 碳的亲电特性

韩梅;施栩翎;杨镇军;蔡孟深   

  1. 北京医科大学药学院
  • 发布日期:1994-04-15

Chemistry of 1,2,4-triazines.XXI. the substituted benzene sulfonation and properties electrophilic addition in 6-carbon of 3-methylthio-5-oxo-2,5-dihydro-1,2,4 triazine

HAN MEI;SHI XULING;YANG ZHENJUN;CAI MENGSHEN   

  • Published:1994-04-15

3-Methylthio-5-oxo-2,5-dihydro-1,2,4-triazine (I) reacted with substituted benzenesulfonyl chlorides, to give 3-methylthio-4-substituted benzenesulfonyl-5-oxo-6-hydroxy-1,4,5,6-tetrahydro-1,2,4-triazines in the solution of NaOH-H2O-CH3COCH3; to give 1-tosyl-3-methylthio-5-oxo-6-methyloxy-1,4,5,6-tetrahydro-1,2,4-triazine in the solution of NaOH-CH3OH. The series of reaction show a anomalous properties of electrophilic addition in 6-carbon of the 1,2,4-triazine ring.

Key words: PYRIDINE P, BENZENE SULFOCHLORIDE

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