Chemistry of hyodeoxycholic acid. 7.   stereo- and regio-selective syntheses of (24R)-24,25-dihydroxy-, (24R,25S)-24,25,26-trihydroxy-and(25R)-25,26-dihydrxycholesterol

Acta Chimica Sinica ›› 1994, Vol. 52 ›› Issue (4): 403-411. Previous Articles Next Articles

Original Articles

猪去氧胆酸化学7.(24R)-24,25-双羟基,(24R,25S)-24,25,26-三羟基和(25R)-25,26-双羟基胆固醇的立体选择性和区域选择性合成

王钟麒;阮奔放

中国科学院上海有机化学研究所

发布日期:1994-04-15

Chemistry of hyodeoxycholic acid. 7. stereo- and regio-selective syntheses of (24R)-24,25-dihydroxy-, (24R,25S)-24,25,26-trihydroxy-and(25R)-25,26-dihydrxycholesterol

WANG ZHONGQI;RUAN BENFANG

Published:1994-04-15

Abstract

(24R)-24,25-dihydroxycholesterol, (24R,25S)-24,25,26-trihydroxycholesterol, and (25R)-25,26-dihydroxycholesterol were prepared in 27, 27, and 38% yield resp. from Me hyodeoxycholanate. The key steps are stereoselective epoxidn. of the allylic alcohol I and regioselective ring opening process of the epoxy alcohol II.

Key words: METABOLITE, STEREOSELECTIVITY, BILE ACID, HYODEOXYCHOLIC ACID, CHOLESTEROL, REGIOSELECTIVITY

CLC Number:

O629

Cite this article

WANG ZHONGQI;RUAN BENFANG. Chemistry of hyodeoxycholic acid. 7. stereo- and regio-selective syntheses of (24R)-24,25-dihydroxy-, (24R,25S)-24,25,26-trihydroxy-and(25R)-25,26-dihydrxycholesterol[J]. Acta Chimica Sinica, 1994, 52(4): 403-411.

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猪去氧胆酸化学7.(24R)-24,25-双羟基,(24R,25S)-24,25,26-三羟基和(25R)-25,26-双羟基胆固醇的立体选择性和区域选择性合成

Chemistry of hyodeoxycholic acid. 7. stereo- and regio-selective syntheses of (24R)-24,25-dihydroxy-, (24R,25S)-24,25,26-trihydroxy-and(25R)-25,26-dihydrxycholesterol

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