Acta Chimica Sinica ›› 1998, Vol. 56 ›› Issue (8): 819-826. Previous Articles     Next Articles

Original Articles

四氢叶酸辅酶结构和性能的模拟及取代一碳单元转移反应的研究

陈建新;潘继刚;夏炽中;程津培   

  1. 山西省大同医学专科学校化学室;山西大学化学系;南开大学化学系
  • 发布日期:1998-08-15

Mimicking of structure and properties of tetrahydrofolic coenzyme and study on their substituted one-carbon unit transfer reactions

CHEN JIANXIN;PAN JIGANG;XIA CHIZHONG;CHENG JINPEI   

  • Published:1998-08-15

Substituted imidazolinium salt, 1, 2-dimethyl-3-(p-methoxybenzenesulfonyl)-imidazolinium iodide, as a tetrahydrofolate model in terms of the ability to transfer a substituted one-carbon unit (ethylidyne, nitromethylethylidene) at the level of formate or formaldehyde, has been synthesized by mimicking the structure and property of tetrahydrofolate coenzyme. The model compound can react with a variety of mono- and bifunctional nucleophiles and lead to some carboline alkaloids and other heterocyclic compounds.

Key words: IMIDAZOLE P, IODINE COMPOUNDS, ORGANIC SYNTHESIS, BIONICS, TETRAHYDRO-COMPOUNDS, C1 COMPOUNDS, FOLIC ACID, TRANSFER REACTIONS, COENZYME, NUCLEOPHILIC REAGENTS

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