An improved synthesis of 8-decyl-benzolactam V8

Acta Chimica Sinica ›› 1999, Vol. 57 ›› Issue (3): 305-311. Previous Articles Next Articles

Original Articles

8-葵炔基苯并内酰胺-V8的改良合成

马大为;王国强

中国科学院上海有机化学研究所.上海(200032);中国科学院生命有机化学国家重点实验室

发布日期:1999-03-15

An improved synthesis of 8-decyl-benzolactam V8

Ma Dawei;Wang Guoqiang

Shanghai Inst Organ Chem., CAS.Shanghai(200032)

Published:1999-03-15

Abstract

8-Decyl-benzolactam-V8 is a new protein kinase C (PKC) activator with some isoform-selectivity, and showes anti-cancer activity in vivo. This paper describes a new synthetic protocol for this compound. By using nitration product of L-phenylalanine derivative as starting material, we obtained the title compound in 22.4% overall yield. The key steps were iodination, DPPA-mediated cyclization and Pd/Cu- catalyzed coupling reaction of aryl iodide with 1-decyne.

Key words: LACTAM P, PALLADIUM, CUPRIC IODIDE, BENZENE P, IODIDE

CLC Number:

O621

Cite this article

Ma Dawei;Wang Guoqiang. An improved synthesis of 8-decyl-benzolactam V8[J]. Acta Chimica Sinica, 1999, 57(3): 305-311.

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8-葵炔基苯并内酰胺-V8的改良合成

An improved synthesis of 8-decyl-benzolactam V8

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