Two dimensional and three dimensional structure - activity relationships of herbicidal triazolopyrimidinyl sulfonamides were studied using Hansch and CoMFA method. The results show that the electronic property and stereo - structure have an important impact on the herbicidal activity. A suitable acidity and steric effect were required for higher activity. Furthermore, the studies also indicate that application Hansch and CoMAF method simultaneously can reflect more completely the structure - activity relationships of drug molecules.

Key words: HERBICIDES, MOLECULAR DESIGN, BIOLOGICAL ACTIVITY, SULFAMIDE P, PYRRODIAZOLE P, PYRIMIDINE P, STRUCTURE AND PROPERTY CORRELATION