Advances and Perspectives on Organic Materials for Neuroelectronic Interface Devices★

doi:10.6023/A23050213

Acta Chimica Sinica ›› 2023, Vol. 81 ›› Issue (9): 1175-1186.DOI: 10.6023/A23050213 Previous Articles Next Articles

Special Issue: 庆祝《化学学报》创刊90周年合辑

Perspective

面向神经电子接口器件的有机材料进展与展望^★

贾凌轩^a^,^b, 詹泽庞^a^,^b, 贺紫晗^a^,^*(), 狄重安^a^,^*(), 朱道本^a

a 中国科学院化学研究所有机固体重点实验室北京 100190
b 中国科学院大学化学科学学院北京 100049

投稿日期:2023-05-07 发布日期:2023-06-29

作者简介:

贾凌轩, 中国科学院化学研究所2020级在读博士生, 2020年获中国科学院大学化学学士学位. 研究方向为柔性可植入有机电子器件.

詹泽庞, 中国科学院化学研究所2021级在读硕博生. 2021年获得暨南大学应用化学学士学位, 研究方向为有机光电材料与器件.

贺紫晗, 中国科学院化学研究所在站博士后. 2022年获得中国科学院大学理学博士学位. 主要研究方向为基于有机晶体管的生物电子器件.

狄重安, 2008年于中科院化学所获得博士学位, 于化学所工作至今, 历任助理研究员、副研究员和研究员, 主要从事有机半导体的电荷输运调控与器件功能化方面的研究工作.

朱道本, 中国科学院化学研究所研究员, 1968年于华东理工大学研究生毕业, 1997年被选为中国科学院院士, 研究领域主要为有机固体, 包括有机导体、超导体, 富勒烯及其衍生物, 分子材料及器件等.

^★庆祝《化学学报》创刊90周年.

基金资助:
国家自然科学基金(22125504); 国家自然科学基金(62075224); 国家自然科学基金(22021002); 卢嘉锡国际团队项目(GJTD-2020-02)

Advances and Perspectives on Organic Materials for Neuroelectronic Interface Devices^★

Lingxuan Jia^a^,^b, Zepang Zhan^a^,^b, Zihan He^a(), Chong-an Di^a(), Daoben Zhu^a

a Key Laboratory of Organic Solid, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China
b School of Chemical Sciences, University of Chinese Academy of Sciences, Beijing 100049, China

Received:2023-05-07 Published:2023-06-29
Contact: *E-mail: hezihan@iccas.ac.cn; dicha@iccas.ac.cn
About author:
^★Dedicated to the 90th anniversary of Acta Chimica Sinica.
Supported by:
The National Natural Science Foundation of China(22125504); The National Natural Science Foundation of China(62075224); The National Natural Science Foundation of China(22021002); The K.C. Wong Education Foundation(GJTD-2020-02)

Neuroelectronic interface devices create a direct connection between the interface of a living organism's nervous system and the digital world, enabling the acquisition, manipulation and feedback of signals and acting as a bridge for two-way interaction between the nervous system and the outside world. Organic materials with multiple weak interactions between molecules are the most similar to living organisms taking account of their molecular structure and mechanical properties as optoelectronic functional materials and are ideal candidates for constructing neural interface materials and devices. This paper summarizes the progress of neuroelectronic interface devices based on organic materials, as well as the strategies for modulating the functional properties of organic materials in terms of both molecular design and aggregation state modulation, and discusses the future directions of neural interface devices.

Key words: neuroelectronic interface, conjugated polymer, electrical signal tenability, mechanical compliance, biocompatibility, molecular design, aggregate states modulation

Cite this article

Lingxuan Jia, Zepang Zhan, Zihan He, Chong-an Di, Daoben Zhu. Advances and Perspectives on Organic Materials for Neuroelectronic Interface Devices^★[J]. Acta Chimica Sinica, 2023, 81(9): 1175-1186.

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Fig. & Tab. 6

Figure 1. (a) Schematic diagram of basic physics properties of interface devices in nervous system. (b) Schematic of functional property requirements of organic materials for neuroelectronic interfaces

Figure 2. (a) Development of neural interface devices using organic materials[21????????-30]. (b) Molecular structure of the included organic materials

Figure 3. Advances in neuroelectronic interfaces based on organic materials. (a) Collection of high sensitivity and high resolution ECG signals through an organic "electrical bioadhesive interface" with very low impedance[32]. (b) OECT array with signal amplification to obtain high spatial and temporal resolution ECG signals[35]. (c~e) Highly mechanically compliant neural interfaces constructed from conductive polymer hydrogels[26]: (c) PEDOT: PSS/EMIM-TFSI hydrogel material and the flexible electrodes it forms, (d) impedance performance during device stretching, (e) low Young's modulus of the material matching nerves. (f, g) Highly biocompatible organic conductor neuroelectronic electrode[27]: (f) PEDOT:PSS/glycerol organic conductor in contact with the sciatic nerve, (g) stable operating time vs. conventional cuff electrode. (h, i) Bioresorbable pacemaker[28]: (h) schematic of device contact with the heart and the hydrolytic absorption reaction, (i) degradation process of the device immersed in PBS biological solution

Figure 4. Organic molecular backbone and side chains design strategies for neuroelectronic interface functions. (a) Schematic of the functionalization requirements of organic materials with molecular backbone and side chain regulation strategies. (b) Strategies to obtain low elastic modulus and high stretchability by embedding non-conjugated fragments in the backbone of the organic semiconductor PDPP4T[60]. (c) Crystallinity reduction and efficient charge transport retention under strain in the organic semiconductor PDPP-C4Ph based on the potential resistance effect of the aryl side chains[66]. (d) Hydrolysable imine bond introduction and bioresorbability of the organic semiconductor PNDIT2 [68]. (e) Dynamic binding effects of hydrogen bonding based on fine tuning of PDMS-IU with its self-healing properties adapted to the nerve growth process [27]

Figure 5. Modulation of the neuroelectronics interface functional properties of organic materials through aggregation states regulation by molecular blending. (a) Different approaches to the regulation of aggregation states of organic materials. (b) Reduction of crystallinity and retention of short-range aggregation states and fibrous structures of organic semiconductors upon cyclic aromatic doping to maintain the mobility of semiconductors during repeated stretching[74], (c) DOP doping of DPPTVT to inhibit large crystal growth and promote short-range aggregation with constant current output of its transistors in the stretched state[75]. (d) PDPPT-TT with SEBS nano-confinement effect and >100% stretchable charge transporting of the blended semiconductor[76]. (e) Nano-confinement effect of PDPPDTSE and SEBS combined with molecular-macroscale ordering modulation by solution shear for both stretchability and high carrier mobility[77]. (f) Double interpenetrating hydrogel formed by a PAA network cross-linked with bisacrylamide and gel PEDOT:PSS, with very low Young's modulus and stretchability[78]. (g) Topological molecular building blocks PEG-CD induced decoupling of the PR/PEDOT:PSS cross-linked network to regulate mechanical and electrical conductivity, with very high conductivity and on-demand stretching conductivity[79]

Figure 6. The key aspects of organic materials for neuroelectronic interfaces that need to be focused on

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面向神经电子接口器件的有机材料进展与展望^★

Advances and Perspectives on Organic Materials for Neuroelectronic Interface Devices^★

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面向神经电子接口器件的有机材料进展与展望★

Advances and Perspectives on Organic Materials for Neuroelectronic Interface Devices★

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Abstract

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Fig. & Tab. 6

References 87

Related Articles 15

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面向神经电子接口器件的有机材料进展与展望^★

Advances and Perspectives on Organic Materials for Neuroelectronic Interface Devices^★