Study of Paracetamol Molecularly Imprinted Polymers Applied to Solid Phase Extraction

Acta Chimica Sinica ›› 2004, Vol. 62 ›› Issue (9): 864-868. Previous Articles Next Articles

扑热息痛分子印迹聚合物应用于固相萃取的研究

胡树国¹, 王善韦², 何锡文¹

1. 吸附分离功能高分子材料国家重点实验室,南开大学化学系,天津,300071;
2. 南开大学中心实验室,天津,300071

投稿日期:2003-06-17 修回日期:2004-01-05 发布日期:2014-02-17
通讯作者: 何锡文,E-mail:xiwenhe@nankai.edu.cn E-mail:何锡文,E-mail:xiwenhe@nankai.edu.cn
基金资助:
国家自然科学基金(Nos.20375017,20175009)、天津市自然科学基金(No.033603511)和教育部博士点基金(No.20020055002)资助项目.

Study of Paracetamol Molecularly Imprinted Polymers Applied to Solid Phase Extraction

HU Shu-Guo¹, WANG Shan-Wei², HE Xi-Wen¹

1. State Key Laboratory of Functional Polymer Materials for Adsorption and Separation Department of Chemistry, Nankai University, Tianjin 300071;
2. Center Lab of Nankai University, Tianjin 300071

Received:2003-06-17 Revised:2004-01-05 Published:2014-02-17

Abstract

Using paracetamol as an imprinted molecule, acrylamide as functional monomers, and EDMA as crosslinking agent, a polymer was prepared by molecular imprinting technique.The polymer was loaded into the self made ssolid-phasaction (SPE) cartridge.A SPE procedure was described for extracting and concentrating paracetamol using water and acetonitrile as the loading solvent.In order to optimize the washing and eluting solution, the adsorption of paracetamol in aqueous solution with the different percentage of methanol was studied.It was found that the paracetamol and two analogues (phenacetin and p-tertiary butylphenol) were separated primely, and the paracetamol content in medicine (Endophy) was determined successfully, with the recovery being 94.3%.

Key words: molecularly imprinted polymer, solid-phase extraction,paracetamol, HPLC

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HU Shu-Guo, WANG Shan-Wei, HE Xi-Wen. Study of Paracetamol Molecularly Imprinted Polymers Applied to Solid Phase Extraction[J]. Acta Chimica Sinica, 2004, 62(9): 864-868.

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扑热息痛分子印迹聚合物应用于固相萃取的研究

Study of Paracetamol Molecularly Imprinted Polymers Applied to Solid Phase Extraction

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