Radiolabeled Synthesis and Identification of a Novel Herbicide, Propyl 4-[2-(4,6-Dimethoxy-2-pyrimidinyloxy)benzylamino]benzoate with All Six Benzoic Ring Carbons Labeled by 14C

Acta Chimica Sinica ›› 2005, Vol. 63 ›› Issue (21): 1999-2003. Previous Articles Next Articles

Original Articles

新型除草剂丙酯草醚A环¹⁴C均标记合成和鉴定

杨征敏¹,3，叶庆富²，唐庆红³，吕龙*^,3，陈子元²

(¹西北农林科技大学生命科学学院咸阳 712100)
(²浙江大学原子核农业科学研究所杭州 310029)
(³中国科学院上海有机化学研究所上海 200032)

投稿日期:2005-05-20 修回日期:2005-07-18 发布日期:2010-12-10
通讯作者: 吕龙

Radiolabeled Synthesis and Identification of a Novel Herbicide, Propyl 4-[2-(4,6-Dimethoxy-2-pyrimidinyloxy)benzylamino]benzoate with All Six Benzoic Ring Carbons Labeled by ¹⁴C

YANG Zheng-Min¹, 3, YE Qing-Fu², TANG Qing-Hong³, LU Long*^{, 3}, CHEN Zi-Yuan²

(¹ College of Life Science, Northwest Science and Technology University of Agriculture and Forestry, Xianyang 712100)
(²Institute of Nuclear-Agricultural Science, Zhejiang University, Hangzhou 310029)
(³Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032)

Received:2005-05-20 Revised:2005-07-18 Published:2010-12-10
Contact: LU Long

Abstract

A radiochemical, propyl 4-[2-(4,6-dimethoxy-2-pyrimidinyloxy)benzylamino]benzoate with all six benzoic ring carbons labeled by ¹⁴C was made from 4-aminobenzoic acid with all six benzoic ring carbons labeled by ¹⁴C through esterification, condensation, reduction and substitution, and purified by preparative HPLC. Its structure was identified by LC-MS and ¹H NMR. HPLC test showed its chemical purity exceeded 98%. HPLC-LSC and TLC-IIA demonstrated that its radiochemical purity exceeded 98% and specific activity was 1.089±0.011 mCi/mmol. The total chemical yield and radiochemical yield were all 53%.

Key words: propyl 4-[2-(4,6-dimethoxy-2-pyrimidinyloxy)benzylamino]benzoate with all six benzoic ring carbons l, radiolabelled synthesis, identification, herbicide

Cite this article

YANG Zheng-Min^{1, 3}, YE Qing-Fu², TANG Qing-Hong³, LU Long*^{, 3}, CHEN Zi-Yuan². Radiolabeled Synthesis and Identification of a Novel Herbicide, Propyl 4-[2-(4,6-Dimethoxy-2-pyrimidinyloxy)benzylamino]benzoate with All Six Benzoic Ring Carbons Labeled by ¹⁴C[J]. Acta Chimica Sinica, 2005, 63(21): 1999-2003.

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新型除草剂丙酯草醚A环¹⁴C均标记合成和鉴定

Radiolabeled Synthesis and Identification of a Novel Herbicide, Propyl 4-[2-(4,6-Dimethoxy-2-pyrimidinyloxy)benzylamino]benzoate with All Six Benzoic Ring Carbons Labeled by ¹⁴C

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新型除草剂丙酯草醚A环14C均标记合成和鉴定