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Acta Chimica Sinica ›› 2007, Vol. 65 ›› Issue (15): 1527-1531. Previous Articles    

Reports

不同加成数C60精氨酸衍生物的合成及其清除活性氧自由基的性能

胡桢, 黄丽珍, 官文超*   

  1. (华中科技大学化学与化工系 武汉 430074)
  • 投稿日期:2006-10-19 修回日期:2007-01-12 发布日期:2007-08-14
  • 通讯作者: 官文超

Synthesis of Arginine C60 Derivatives with Different Addition Numbers and Their Active Oxygen Radical Scavenging Ability

HU Zhen; HUANG Li-Zhen; GUAN Wen-Chao*   

  1. (Department of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan 430074)
  • Received:2006-10-19 Revised:2007-01-12 Published:2007-08-14
  • Contact: GUAN Wen-Chao

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Three water-soluble arginine C60 derivatives with different addition numbers were synthesized for the first time, C60[HNC(NH)NH(CH2)3CH(NH2)COOH]nHn (n＝2, 6, 8). The products were characterized by FT-IR, UV, RF, 1H NMR, 13C NMR, LC-MS, elemental analysis, DLS particle-size analysis and TEM. Meanwhile, the scavenging ability to superoxygen anion radical O2－. and hydroxyl radical •OH was studied by chemiluminescence. It was found that arginine C60 derivatives showed excellent efficiency in eliminating superoxygen anion radical and hy-droxyl radical. The efficiency should be related with many factors, such as donor effect of amino group, steric effect and morphology of the aggregates.

Key words: arginine C60 derivative, superoxygen anion radical, hydroxyl radical, chemiluminescence, self-assembly