Two new cyclic peroxides are reported. The peroxy bond in each compound was derived from hydrogen peroxide. The synthesis of the first compound explored the feasibility of using an intramolecular Michael addition to a trisubstituted C—C double bond to close the peroxy ring, while that of the second utilized a Hg(II)-mediated ring-closure to construct the seven-membered peroxy ring.

Key words: peroxide, antimalarial, synthesis, hydrogen peroxide, cyclization