Hydrothermal Synthesis of Metal-Chelated Magnetic Nanobeads for Exclusive Use of Peptides Extraction by Mass Spectrum

Abstract

A novel hydrothermal route has been developed to produce metal-chelated magnetic nanobeads which help to study serum peptides profiles by matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrum. The obtained particles were analyzed by TEM, AFM and FT-IR techniques, and it showed that the average particle size ranged between 70～90 nm. It is validated by mass spectrum that the metal-chelated magnetic nanobeads can extract serum peptides in an effective way. These beads are very useful in the clinic studies on serum preparation for mass spectrum in future.

Key words: hydrothermal method, mass spectrum, peptide, metal-chelated magnetic nanobead

Cite this article

WANG Na^†,1; DONG Fang-Ting^†,2; ZHANG Xue-Min²; LI Ai-Ling²; WANG Jie²; WANG Hong-Xia²; LI Ping²; WU Sheng-Ming²; YANG Xiao-Hong*^,1. Hydrothermal Synthesis of Metal-Chelated Magnetic Nanobeads for Exclusive Use of Peptides Extraction by Mass Spectrum[J]. Acta Chimica Sinica, 2007, 65(4): 344-348.

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水热法制备质谱专用提取多肽的金属螯合纳米磁珠