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Acta Chimica Sinica ›› 2008, Vol. 66 ›› Issue (1): 138-140. Previous Articles     Next Articles

Reports

含叶酸功能端基Pluronic F127的合成及其在水中的形态

邵芳可1，吴唯1，查刘生2，张琰*,1   

  1. (1超细材料制备与应用教育部重点实验室 华东理工大学材料科学与工程学院 上海 200237)
    (2东华大学分析测试中心 上海 200051)
  • 投稿日期:2007-07-12 修回日期:2007-08-17 发布日期:2008-01-14
  • 通讯作者: 张琰

Synthesis of Folic Acid Conjugated Pluronic F127 and Their Morphology in Water

SHAO Fang-Ke1 WU Wei1 ZHA Liu-Sheng2 ZHANG Yan*,1   

  1. (1 Key Laboratory for Ultrafine Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237)
    (2 Research Center for Analysis and Measurement, Donghua University, Shanghai 200051)
  • Received:2007-07-12 Revised:2007-08-17 Published:2008-01-14
  • Contact: ZHANG Yan

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The end hydroxyls of triblock copolymer Pluronic F127 have been modified to amino-groups by a series of reactions. Using the macromonomer aminating F127, the bioactive macromolecular folic acids which are as the targeting ligand have been conjugated to the end group of F127. 1H-NMR and FT-IR were adopted to characterize the structures of copolymers Amphiphilic F127-Folate self-assembled into micelles by dialysis method. The morphologies of the aggregates were investigated by TEM. The results proved that F127-Folate can self-assemble into nanomicelles in water.

Key words: Pluronic F127, Folic acid, Self-assembly, micelles