Identification and Free Radical Scavenging Activity of Lignanamide  Extract from Fructus Cannabis of Bama

Acta Chimica Sinica ›› 2009, Vol. 67 ›› Issue (7): 700-704. Previous Articles Next Articles

Original Articles

巴马火麻仁木脂素酰胺类提取物的鉴定及清除自由基活性的研究

吴娜a,b 沈谦a,b 蔡光明*,a 赵艳玲a 何群b 王峰a

(a中国人民解放军302医院中药研究所北京 100039)
(b湖南中医药大学长沙 410208)

投稿日期:2008-09-16 修回日期:2008-10-15 发布日期:2009-04-14
通讯作者: 蔡光明

Identification and Free Radical Scavenging Activity of Lignanamide Extract from Fructus Cannabis of Bama

Wu, Na ^a,b Shen, Qian ^a,b Cai, Guangming ^*,a Zhao, Yanling ^aHe, Qun ^b Wang, Feng ^a

(a Institute of Chinese Materia Medica, No. 302 Hospital of PLA, Beijing 100039)
(b Hunan University of Traditional Chinese Medicine, Changsha 410208)

Received:2008-09-16 Revised:2008-10-15 Published:2009-04-14
Contact: Cai, Guangming

Abstract

Cannabisin A was isolated from the crude lignanamides of Fructus Cannabis of Bama with chloroform-methanol (85∶15, V∶V) on silica gel column chromatography, and identified by FAB-MS and NMR. The scavenging activity of the crude lignanamides, fine lignanamides purified by macroporous resin and cannabisin A was studied by three different free radical systems such as 1,1-diphenyl-2-picryl-hydrazyl free radical (DPPH•), superoxide anion free radical and hydroxide free radical (OH•). The results showed that all of them had significant scavenging activity with dose dependent relationship in a certain dose range. The scavenging activity of fine lignanamides was strongest especially in the OH• system with the 13 times of the crude lignanamides activity.

Key words: Fructus Cannabis, lignanamide, cannabisin A, free radical, identification, Bama

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巴马火麻仁木脂素酰胺类提取物的鉴定及清除自由基活性的研究

Identification and Free Radical Scavenging Activity of Lignanamide Extract from Fructus Cannabis of Bama

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