Acta Chimica Sinica ›› 2010, Vol. 68 ›› Issue (14): 1431-1436. Previous Articles     Next Articles

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(R)-苯并四咪唑催化的α-位带有官能团的苄醇类化合物的动力学拆分研究

陈沛然*,张怡,周辉,徐青   

  1. (东华大学化学化工与生物工程学院 上海 201620)
  • 投稿日期:2010-05-16 修回日期:2010-05-27 发布日期:2010-05-28
  • 通讯作者: 陈沛然 E-mail:prchensioc@hotmail.com
  • 基金资助:

    中央高校基本科研业务费专项资金

A Study on the Kinetic Resolution of Benzyl Alcohols Bearing Functional Group on α-Position Catalyzed by (R)-Benzotetramisole Catalyst

CHEN Pei-Ran, ZHANG Yi, ZHOU Hui, XU Qing   

  1. (College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620)
  • Received:2010-05-16 Revised:2010-05-27 Published:2010-05-28
  • Contact: Peiran Chen E-mail:prchensioc@hotmail.com

Kinetic resolution of a series of benzyl alcohols bearing functional group on α-position catalyzed by (R)-benzotetramisole catalyst has been investigated. The competition between the cation-π interaction of the aryl ring of the substrates with the catalyst and the cation-π interaction of the functional group s π-system with the catalyst led to the decrease of the stereo-selectivity of the reaction and the configuration change of the products.

Key words: kinetic resolution, benzyl alcohols, (R)-benzotetramisole catalyst