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Acta Chimica Sinica ›› 2010, Vol. 68 ›› Issue (24): 2500-2508. Previous Articles Next Articles
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贾雪冰,张鋆,孙宏伟*,陈兰,沈荣欣,赖城明
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国家高技术研究发展专项经费
JIA Xue-Bing, ZHANG Jun, SUN Hong-Wei, CHEN Lan, SHEN Rong-Xin, LAI Cheng-Ming
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The molecular dynamics simulation studies on the 14 auxin perception systems that comprise auxins, receptor TIR1, cofactor InsP6 and IAA7 substrate peptide are carried out to investigate the interaction mode between receptor TIR1 and the four auxins of IAA, 1-NAA, 2,4-D and 2-NAA, respectively. The importance of cofactor InsP6 and IAA7 substrate peptide in early auxin perception was also discussed. MD simulations show that the binding intensity between auxins and TIR1 is consistent with auxin activity|the molecular structure has an important impact on auxin activity|multiple center-waters pull auxins to suitable position where auxins can strongly bind with TIR1 through the hydrogen bonds|the hydrogen bonds between InsP6 and TIR1 make the binding pocket stable to ensure auxins to bind effectly|in addition, IAA7 becomes more active after binding with auxins, which means auxins ignite the activity of IAA7 as the trigger to induce the further gene expression of auxin perception.
Key words: auxin perception, receptor TIR1, IAA7 substrate peptide, MD simulation
CLC Number:
O641
JIA Xue-Bing, ZHANG Jun, SUN Hong-Wei, CHEN Lan, SHEN Rong-Xin, LAI Cheng-Ming. Molecular Dynamics Simulation Study on the Interaction Mode of Auxin Perception[J]. Acta Chimica Sinica, 2010, 68(24): 2500-2508.
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