Acta Chimica Sinica ›› 1997, Vol. 55 ›› Issue (6): 611-616. Previous Articles     Next Articles

Original Articles

用反Diels-Alder反应合成天然产物XIV. 立体控制合成(±)-环 氧菌素和(±)- 4-表环氧菌素

刘志煜;李恒光;陈淑华   

  1. 中国科学院上海有机化学研究所.上海(200032);四川大学化学系.成都(610064)
  • 发布日期:1997-06-15

Natural products synthesis by retro Diels-Alder reaction XIV. Stereospecific synthesis of (±)-epoformin and (± )-epiepoformin

Liu Zhiyu;Li Hengguang;Chen Shuhua   

  1. Shanghai Inst Organ Chem., CAS.Shanghai(200032);Sichuan Univ, Dept Chem.Chengdu(610064)
  • Published:1997-06-15

p-Benzoquinone reacted with cyclopentadiene to mask its double bond. After introduction of the necessary functional groups and substituent, retro Diels-Alder reaction gave (± )-epiepoformin, which was converted into (±)-epoformin by inversion of its hydroxy configuration in 70% and 65% overall yields, respectively.

Key words: NATURAL PRODUCTS, DIELS-ALDER REACTION, CYCLOPENTADIENE, BENZOQUINONE

CLC Number: