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Acta Chimica Sinica ›› 2008, Vol. 66 ›› Issue (14): 1658-1662. Previous Articles     Next Articles

基于HPMCP包覆介孔SBA-15的pH敏感药物缓释系统

徐武军a,b 高 强a,b 徐 耀*,a 吴 东a 孙予罕a   

  1. (a中国科学院山西煤炭化学研究所 煤转化国家重点实验室 太原 030001)
    (b中国科学院研究生院 北京 100049)
  • 投稿日期:2007-10-10 修回日期:2008-01-04 发布日期:2008-07-28
  • 通讯作者: 徐耀

SBA-15 Tablet Coated with HPMCP for pH-Sensitive Drug Release System

XU, Wu-Jun a,b GAO, Qiang a,b XU, Yao *,a WU, Dong a SUN, Yu-Han a   

  1. (a State Key Laboratory of Coal Conversion, Institute of Coal Chemistry, Chinese Academy of Sciences, Taiyuan 030001)
    (b Graduate University of the Chinese Academy of Sciences, Beijing 100049)
  • Received:2007-10-10 Revised:2008-01-04 Published:2008-07-28
  • Contact: XU, Yao

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A novel pH-sensitive drug release system was fabricated by coating hydroxypropyl methylcellulose phthalate (HPMCP) on a drug-loaded SBA-15 tablet. Two kinds of release media, including simulated gastric fluid (SGF, pH＝1.2) and simulated intestinal fluid (SIF, pH＝7.5), were used to study the different drug release behavior of the system SBA-15/HPMCP. In SGF, due to the compact HPMCP coating on the SBA-15 tablet, the coating material could effectively delay the release rate of famotidine (Famo). But in SIF, because HPMCP could be quickly dissolved into the release medium, no obvious effect of the coating material on the drug delivery rate was found. Therefore, this novel system would have a potential application to targeting intestinal drug release.

Key words: mesoporous material, pH-sensitive, drug release