New method for synthesis of tricyclic morphine analog

Acta Chimica Sinica ›› 1990, Vol. 48 ›› Issue (10): 1030-1035. Previous Articles Next Articles

Original Articles

三环型吗啡类似物合成的新方法

张勇民;张礼和;刘维勤;Thal, C.;Labidalle, S.

北京医科大学药学院;法国天然产物化学研究所;巴黎南大学药学院

发布日期:1990-10-15

New method for synthesis of tricyclic morphine analog

ZHANG YONGMIN;ZHANG LIHE;LIU WEIQIN;Thal, C.;Labidalle, S.

Published:1990-10-15

Abstract

A tricyclic morphine analog I was prepared starting from phenylcyclohexenal II in 9 steps in 46% overall yield.

Key words: EPOXIDATION REACTION, PHENYLETHYLAMINE P, MORPHINUM, SUBSTITUTION REACTION, REDUCTION, CYCLIZATION, REARRANGEMENT REACTION, ENOLS, N-METHYL GROUP, BENZOFURAN P

CLC Number:

O621
R91

Cite this article

ZHANG YONGMIN;ZHANG LIHE;LIU WEIQIN;Thal, C.;Labidalle, S.. New method for synthesis of tricyclic morphine analog[J]. Acta Chimica Sinica, 1990, 48(10): 1030-1035.

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三环型吗啡类似物合成的新方法

New method for synthesis of tricyclic morphine analog

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