HPLC Study on Interaction of Cucurbit(n)uril (n＝6,7) with Phenylenediamine and Nitroaniline Isomers

Acta Chimica Sinica ›› 2007, Vol. 65 ›› Issue (11): 1045-1050. Previous Articles Next Articles

Original Articles

六、七元瓜环与苯二胺及硝基苯胺异构体相互作用的HPLC研究

董南¹,2, 薛赛凤*^,2, 陶朱², 赵昱¹

(¹浙江大学药学院天然产物研究室杭州 310058)
(²贵州大学应用化学研究所贵阳 550025)

投稿日期:2006-11-10 修回日期:2006-12-20 发布日期:2007-06-14
通讯作者: 薛赛凤

HPLC Study on Interaction of Cucurbit(n)uril (n＝6,7) with Phenylenediamine and Nitroaniline Isomers

DONG Nan¹,2; XUE Sai-Feng*^,2; TAO Zhu²; ZHAO Yu¹

(¹Institute of Natural Product, College of Pharmacy, Zhejiang University, Hangzhou 310058)
(²Institute of Applied Chemistry, Guizhou University, Guiyang 550025)

Received:2006-11-10 Revised:2006-12-20 Published:2007-06-14
Contact: XUE Sai-Feng

Abstract

Interaction of cucurbit(n)uril (n＝6,7) with aniline and its derivatives was studied by using high performance liquid chromatography (HPLC). The guests are o-phenylenediamine (g1), m-phenylenediamine (g2), p-phenylenediamine (g3), o-nitroaniline (g4), m-nitroaniline (g5) and p-nitroaniline (g6). The experimental results revealed that Q[6] bound only g1～g3 and g5 respectively to form the inclusion complex in a rario of 1∶1; while Q[7] was observed to form a 1∶1 host-guest product with guests g1～g6 respectively. The stability constants and ratio of host∶guest were determined. And the interaction model of the inclusion complexes was proposed, which were further confirmed by UV absorption spectroscopy and ¹H NMR technique.

Key words: HPLC, UV absorption spectroscopy, ¹H NMR, cucurbit(n)uril, stability constant

Cite this article

DONG Nan^1,2; XUE Sai-Feng*^,2; TAO Zhu²; ZHAO Yu. HPLC Study on Interaction of Cucurbit(n)uril (n＝6,7) with Phenylenediamine and Nitroaniline Isomers[J]. Acta Chimica Sinica, 2007, 65(11): 1045-1050.

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六、七元瓜环与苯二胺及硝基苯胺异构体相互作用的HPLC研究

HPLC Study on Interaction of Cucurbit(n)uril (n＝6,7) with Phenylenediamine and Nitroaniline Isomers

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