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Acta Chimica Sinica ›› 2009, Vol. 67 ›› Issue (14): 1615-1620. Previous Articles     Next Articles

Original Articles

基于多壁碳纳米管修饰电极的保泰松的电致化学发光检测

陈毅挺*,a,b 何伟文a,b 林 棋a 娄本勇a 陈国南*,b

  

  1. (a闽江学院化学与化学工程系 福州 350108)
    (b福州大学食品安全与检测技术教育部重点实验室 福州 350002)

  • 投稿日期:2008-12-16 修回日期:2009-02-25 发布日期:2009-07-28
  • 通讯作者: 陈毅挺

Electrochemiluminescence Determination of Phenylbutazone Based on Modified Electrode by Multi-wall Carbon Nanotube

Chen, Yiting *,a,b He, Weiwen a,b Lin, Qi a Lou, Benyong a Chen, Guonan *,b

  

  1. (a Department of Chemistry and Chemical Engineering, Minjiang University, Fuzhou 350108)
    (b Ministry of Education Key Laboratory of Analysis and Detection for Food Safety (Fuzhou University),
    Fuzhou 350002)
  • Received:2008-12-16 Revised:2009-02-25 Published:2009-07-28
  • Contact: Chen, Yiting

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Phenylbutazone (PB) was found to be able to enhance the electrochemiluminescence (ECL) of system, based on which, a novel ECL method for the determination of PB at a multi-wall carbon nanotube (MWNT) modified glassy carbon electrode (GCE) was developed. The effect of enhanced ECL by PB was highest in the 0.05 mol/L pH 10.20 Na2HPO4-NaOH buffer with 1.0×10－5 mol/L . Under the optimum conditions, the enhanced ECL intensity was linear with PB concentration in the range of 0.5～200 μmol/L. The detection limit (defined as S/N＝3) was 0.2 μmol/L, which is lower than that on a bare GCE by one order of magnitude. The method was successfully applied to the determination of PB in a spiked human serum sample, and the results were satisfactory with the recoveries of 85.3%～95.0%. The developed detection method for PB is hopeful to be applied to clinical drug analysis and quality control.

Key words: phenylbutazone, tris(2,2-bipyridyl)ruthenium, electrochemiluminescence