A rapid analysis method based on matrix solid-phase dispersion (MSPD) and high pressure liquid chromatography (HPLC) was established to analyze three kinds of organophosphorus pesticide residues in ginseng. The HPLC method was applied to determine organophosphorus pesticide residues. Al2O3 was used as dispersant, and the mixed solution of acetic ester and hexane with an 8% volume proportion was used as eluant. The quality control problem of this analytical method was discussed particularly. The qualitative and quantitative analysis were performed exactly for different varieties of ginsengs. The linear range of this method was 0.20～10.0 mg•L－1, and the linear correlation coefficient (R) was higher than 0.99815. The relative standard deviation (RSD) was less than 11.54% with the recovery values ranging from 87.29% to 92.43%. The limit of detection (LOD) was lower than 0.017 mg•L－1. The method indexes of linear range, accuracy, precision and LOD can well satisfy the request of organophosphorus pesticide residue analysis.

Key words: MSPD, HPLC, ginseng, organophosphorus pesticide